STRINGSTRING
tnfb tnfb casp3a casp3a hsp70.3 hsp70.3 gpx1b gpx1b gpx8 gpx8 gpx1a gpx1a hsp90aa1.1 hsp90aa1.1 casp9 casp9 gsr gsr sod2 sod2 gpx3 gpx3 casp3b casp3b gpx4a gpx4a casp8 casp8 il10 il10 gpt2 gpt2 hsp70.1 hsp70.1 gpt2l gpt2l gpx7 gpx7 gpx9 gpx9 il6 il6 ENSDARP00000134476 ENSDARP00000134476 il1b il1b gpx4b gpx4b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
hsp70.3Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. (643 aa)
gpx1bGlutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
gpx8Probable glutathione peroxidase 8; Belongs to the glutathione peroxidase family. (210 aa)
gpx1aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (191 aa)
hsp90aa1.1Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] (725 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (436 aa)
gsrGlutathione reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (425 aa)
sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
gpx3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (222 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
gpx4aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
casp8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (476 aa)
il10Interleukin-10. (180 aa)
gpt2Glutamic pyruvate transaminase (alanine aminotransferase) 2. (545 aa)
hsp70.1Heat shock cognate 70-kd protein, tandem duplicate 1; Belongs to the heat shock protein 70 family. (643 aa)
gpt2lAlanine aminotransferase 2-like; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. (562 aa)
gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
gpx9Glutathione peroxidase; Belongs to the glutathione peroxidase family. (140 aa)
il6Interleukin 6 (interferon, beta 2). (231 aa)
ENSDARP00000134476Si:ch211-217a12.1. (488 aa)
il1bInterleukin-1. (284 aa)
gpx4bGlutathione peroxidase; Belongs to the glutathione peroxidase family. (170 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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