STRINGSTRING
uhrf1 uhrf1 irf9 irf9 nfkb2 nfkb2 tp53 tp53 isg15 isg15 tnfrsf1b tnfrsf1b irf7 irf7 mavs mavs slc45a2 slc45a2 ifnphi1 ifnphi1 stat1a stat1a fabp10a fabp10a tnfb tnfb ifnphi2 ifnphi2 rplp0 rplp0 myl7 myl7 endog endog
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
uhrf1E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] (775 aa)
irf9Interferon regulatory factor 9. (428 aa)
nfkb2Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100). (902 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
isg15ISG15 ubiquitin-like modifier. (157 aa)
tnfrsf1bTumor necrosis factor receptor superfamily, member 1B. (425 aa)
irf7Interferon regulatory factor 7. (422 aa)
mavsMitochondrial antiviral-signaling protein. (364 aa)
slc45a2Solute carrier family 45 member 2. (554 aa)
ifnphi1Interferon phi 1. (185 aa)
stat1aSignal transducer and activator of transcription. (749 aa)
fabp10aFatty acid-binding protein 10-A, liver basic; Binds hydrophobic ligands, such as cholate, in the cytoplasm. May be involved in intracellular lipid transport (By similarity). Binds one cholate per subunit. (126 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
ifnphi2Type I interferon 2. (181 aa)
rplp060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10; Belongs to the universal ribosomal protein uL10 family. (316 aa)
myl7Myosin, light polypeptide 7, regulatory. (172 aa)
endogEndonuclease. (306 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.