STRINGSTRING
pla2g4aa pla2g4aa vaspb vaspb pxnb pxnb bin1b bin1b pld1b pld1b egf egf cav2 cav2 tes tes ackr3b ackr3b acta1b acta1b cxcl12a cxcl12a trim9 trim9 ptk2ab ptk2ab wasb wasb jak1 jak1 cfl1 cfl1 rhoab rhoab isl1 isl1 rho rho zgc:172270 zgc:172270 plek2 plek2 wasa wasa cttn cttn amph amph cav3 cav3 cfl1l cfl1l cfl2 cfl2 tln2b tln2b pxna pxna cav1 cav1 tln2a tln2a tln1 tln1 plek plek cdc42 cdc42 pld2 pld2 pld1a pld1a hcls1 hcls1 ccr7 ccr7 zyx zyx loxa loxa loxl1 loxl1 vcla vcla rabif rabif tiam1a tiam1a piezo1 piezo1 vclb vclb zgc:158296 zgc:158296 ccl25b ccl25b src src
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pla2g4aaCytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (741 aa)
vaspbVasodilator-stimulated phosphoprotein b. (445 aa)
pxnbPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (525 aa)
bin1bBridging integrator 1b. (364 aa)
pld1bPhospholipase. (1042 aa)
egfEpidermal growth factor. (1114 aa)
cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
tesTestis-derived transcript (3 LIM domains). (541 aa)
ackr3bAtypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family. (362 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
cxcl12aChemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
trim9Tripartite motif-containing 9. (699 aa)
ptk2abProtein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1050 aa)
wasbWASP actin nucleation-promoting factor b. (479 aa)
jak1Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures. (1153 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
rhoRhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (354 aa)
zgc:172270Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (185 aa)
plek2Plek2 protein. (361 aa)
wasaWASP actin nucleation-promoting factor a. (630 aa)
cttnCortactin. (536 aa)
amphAmphiphysin. (784 aa)
cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (150 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
tln2bTalin 2b. (1537 aa)
pxnaPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (532 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
tln2aTalin 2a. (2543 aa)
tln1Talin 1. (2544 aa)
plekPleckstrin. (352 aa)
cdc42Cell division cycle 42. (191 aa)
pld2Phospholipase. (927 aa)
pld1aPhospholipase. (1022 aa)
hcls1Hematopoietic cell-specific Lyn substrate 1. (548 aa)
ccr7Chemokine (C-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (385 aa)
zyxZyxin. (608 aa)
loxaLysyl oxidase a. (408 aa)
loxl1Lysyl oxidase-like 1. (526 aa)
vclaVinculin a. (1131 aa)
rabifRAB-interacting factor. (132 aa)
tiam1aTIAM Rac1-associated GEF 1a. (1621 aa)
piezo1Piezo-type mechanosensitive ion channel component. (2436 aa)
vclbVinculin b. (987 aa)
zgc:158296Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (171 aa)
ccl25bChemokine (C-C motif) ligand 25b. (106 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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