node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acta1b | flt4 | ENSDARP00000058628 | ENSDARP00000133227 | Actin alpha 1, skeletal muscle b. | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | 0.528 |
acta1b | lyve1b | ENSDARP00000058628 | ENSDARP00000155383 | Actin alpha 1, skeletal muscle b. | Lymphatic vessel endothelial hyaluronic receptor 1b. | 0.472 |
acta1b | notch1a | ENSDARP00000058628 | ENSDARP00000137942 | Actin alpha 1, skeletal muscle b. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.876 |
acta1b | vegfc | ENSDARP00000058628 | ENSDARP00000092263 | Actin alpha 1, skeletal muscle b. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.541 |
angpt2a | flt4 | ENSDARP00000140347 | ENSDARP00000133227 | Angiopoietin 2a. | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | 0.867 |
angpt2a | lyve1b | ENSDARP00000140347 | ENSDARP00000155383 | Angiopoietin 2a. | Lymphatic vessel endothelial hyaluronic receptor 1b. | 0.482 |
angpt2a | notch1a | ENSDARP00000140347 | ENSDARP00000137942 | Angiopoietin 2a. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.553 |
angpt2a | vegfc | ENSDARP00000140347 | ENSDARP00000092263 | Angiopoietin 2a. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.736 |
angpt2a | vegfd | ENSDARP00000140347 | ENSDARP00000121602 | Angiopoietin 2a. | Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. | 0.560 |
angpt2b | flt4 | ENSDARP00000070502 | ENSDARP00000133227 | Angiopoietin 2b. | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | 0.911 |
angpt2b | lyve1b | ENSDARP00000070502 | ENSDARP00000155383 | Angiopoietin 2b. | Lymphatic vessel endothelial hyaluronic receptor 1b. | 0.605 |
angpt2b | notch1a | ENSDARP00000070502 | ENSDARP00000137942 | Angiopoietin 2b. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.603 |
angpt2b | vegfc | ENSDARP00000070502 | ENSDARP00000092263 | Angiopoietin 2b. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.751 |
angpt2b | vegfd | ENSDARP00000070502 | ENSDARP00000121602 | Angiopoietin 2b. | Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. | 0.595 |
flt4 | acta1b | ENSDARP00000133227 | ENSDARP00000058628 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Actin alpha 1, skeletal muscle b. | 0.528 |
flt4 | angpt2a | ENSDARP00000133227 | ENSDARP00000140347 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Angiopoietin 2a. | 0.867 |
flt4 | angpt2b | ENSDARP00000133227 | ENSDARP00000070502 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Angiopoietin 2b. | 0.911 |
flt4 | lyve1a | ENSDARP00000133227 | ENSDARP00000104347 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Lymphatic vessel endothelial hyaluronic receptor 1a. | 0.753 |
flt4 | lyve1b | ENSDARP00000133227 | ENSDARP00000155383 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Lymphatic vessel endothelial hyaluronic receptor 1b. | 0.954 |
flt4 | notch1a | ENSDARP00000133227 | ENSDARP00000137942 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.834 |