STRINGSTRING
il10 il10 mxc mxc eef1a2 eef1a2 eif3d eif3d tlr3 tlr3 rsad2 rsad2 stat1a stat1a pabpc1a pabpc1a pabpc1b pabpc1b cd74b cd74b rpl32 rpl32 mxa mxa irf7 irf7 si:dkey-37o8.1 si:dkey-37o8.1 mxb mxb eef1a1a eef1a1a ccl19b ccl19b eef1a1b eef1a1b ifng1 ifng1 tlr5a tlr5a tlr5b tlr5b ighv4-5 ighv4-5 hamp hamp eif4a3 eif4a3 ddx54 ddx54 il1b il1b eef1a1l1 eef1a1l1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
il10Interleukin-10. (180 aa)
mxcInterferon-induced GTP-binding protein MxC; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (626 aa)
eef1a2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (463 aa)
eif3dEukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs. (552 aa)
tlr3Toll-like receptor 3; Belongs to the Toll-like receptor family. (903 aa)
rsad2Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon; Belongs to the radical SAM superfamily. RSAD2 family. (359 aa)
stat1aSignal transducer and activator of transcription. (749 aa)
pabpc1aPolyadenylate-binding protein 1A; Binds the poly(A) tail of mRNA (By similarity). Prevents mRNA deadenylation and confers poly(A) stability (By similarity). Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl (By similarity). Involved in the maternal-to-zygotic transition in early embryo via interaction with ybx1: interaction recruits pabpc1a on C5-methylcytosine (m5C)-containing maternal mRNAs, preventing their degradation. Belongs to the polyadenylate-binding protein type-1 family. (634 aa)
pabpc1bPolyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (634 aa)
cd74bCD74 molecule, major histocompatibility complex, class II invariant chain b. (198 aa)
rpl32Ribosomal protein L32. (135 aa)
mxaInterferon-induced GTP-binding protein MxA; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (632 aa)
irf7Interferon regulatory factor 7. (422 aa)
si:dkey-37o8.1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (483 aa)
mxbInterferon-induced GTP-binding protein MxB; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (627 aa)
eef1a1aElongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
ccl19bChemokine (C-C motif) ligand 19b. (128 aa)
eef1a1bElongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
ifng1Interferon gamma 1. (179 aa)
tlr5aToll-like receptor 5a; Belongs to the Toll-like receptor family. (881 aa)
tlr5bToll-like receptor 5b; Belongs to the Toll-like receptor family. (881 aa)
ighv4-5Immunoglobulin heavy variable 5-3. (121 aa)
hampHepcidin-2; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family. (91 aa)
eif4a3Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the [...] (406 aa)
ddx54ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (862 aa)
il1bInterleukin-1. (284 aa)
eef1a1l1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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