STRINGSTRING
bnip3la bnip3la cgas cgas cycsb cycsb caspa caspa namptb namptb cdh23 cdh23 psen2 psen2 casp3a casp3a C13H9orf72 C13H9orf72 tomm40 tomm40 apaf1 apaf1 park7 park7 ENSDARP00000149692 ENSDARP00000149692 ENSDARP00000142481 ENSDARP00000142481 hist2h3ca1 hist2h3ca1 prkn prkn diabloa diabloa cdh1 cdh1 psen1 psen1 tbk1 tbk1 pxdn pxdn ENSDARP00000130514 ENSDARP00000130514 maptb maptb LOC799006 LOC799006 zgc:162611-2 zgc:162611-2 apoc1 apoc1 ghrl ghrl bcl2a bcl2a cdh23-2 cdh23-2 tyrobp tyrobp F1QN57_DANRE F1QN57_DANRE HTRA2 HTRA2 tp53 tp53 ungb ungb insb insb ulk1b ulk1b caspbl caspbl ank1a ank1a ncoa3 ncoa3 gba gba bcl2l11 bcl2l11 h3f3a-2 h3f3a-2 zgc:113983 zgc:113983 ogg1 ogg1 hist1h4l hist1h4l plcg2 plcg2 pld1b pld1b LOC563933 LOC563933 casp3b casp3b nampta nampta htt htt zgc:173552 zgc:173552 unga unga fundc1 fundc1 tardbp tardbp ptk2bb ptk2bb tlr2 tlr2 ache ache ins ins casp9 casp9 bnip3lb bnip3lb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bnip3laBCL2/adenovirus E1B interacting protein 3-like, 2. (233 aa)
cgasCyclic GMP-AMP synthase. (592 aa)
cycsbCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (104 aa)
caspaCaspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] (383 aa)
namptbNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (498 aa)
cdh23Cadherin-related 23. (2883 aa)
psen2Presenilin-2; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors; Belongs to the peptidase A22A family. (441 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
C13H9orf72Zgc:100846. (462 aa)
tomm40Translocase of Outer mitochondrial membrane 40 homolog (Yeast). (344 aa)
apaf1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). (1261 aa)
park7Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] (189 aa)
ENSDARP00000149692Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (527 aa)
ENSDARP00000142481Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
hist2h3ca1Histone H3; Belongs to the histone H3 family. (136 aa)
prknE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (458 aa)
diabloaDiablo, IAP-binding mitochondrial protein a. (265 aa)
cdh1Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa)
psen1Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. (456 aa)
tbk1TANK-binding kinase 1. (727 aa)
pxdnPeroxidasin. (1460 aa)
ENSDARP00000130514Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (484 aa)
maptbMicrotubule-associated protein. (309 aa)
LOC799006Si:dkey-265c15.6. (266 aa)
zgc:162611-2Si:dkey-108k21.24. (151 aa)
apoc1Apolipoprotein C-I. (85 aa)
ghrlGhrelin/obestatin prepropeptide. (104 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
cdh23-2Cadherin-related 23. (436 aa)
tyrobpTransmembrane immune-signaling adaptor TYROBP. (115 aa)
F1QN57_DANRESi:dkey-145c18.3. (714 aa)
HTRA2Si:dkey-84o3.4. (200 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
ungbUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (250 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
ulk1bUnc-51-like autophagy-activating kinase 1. (1011 aa)
caspblCaspase b,-like; Belongs to the peptidase C14A family. (409 aa)
ank1aAnkyrin 1, erythrocytic a. (152 aa)
ncoa3Nuclear receptor coactivator 3. (1497 aa)
gbaGlucosylceramidase. (518 aa)
bcl2l11BCL2-like 11. (176 aa)
h3f3a-2Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
zgc:113983Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
ogg18-oxoguanine DNA glycosylase. (391 aa)
hist1h4lHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
plcg21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1240 aa)
pld1bPhospholipase. (1042 aa)
LOC563933Serine protease; Belongs to the peptidase S1B family. (374 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
namptaNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (493 aa)
httHuntingtin. (3121 aa)
zgc:173552Histone H3; Belongs to the histone H3 family. (136 aa)
ungaUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (291 aa)
fundc1FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control; Belongs to the FUN14 family. (152 aa)
tardbpTAR DNA-binding protein. (412 aa)
ptk2bbProtein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1004 aa)
tlr2Toll-like receptor 2. (788 aa)
acheAcetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. (634 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (436 aa)
bnip3lbBCL2-interacting protein 3-like b. (213 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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