node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acta1b | ccnd1 | ENSDARP00000058628 | ENSDARP00000140550 | Actin alpha 1, skeletal muscle b. | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. | 0.670 |
acta1b | cdh2 | ENSDARP00000058628 | ENSDARP00000003949 | Actin alpha 1, skeletal muscle b. | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. | 0.935 |
acta1b | cycsb | ENSDARP00000058628 | ENSDARP00000034555 | Actin alpha 1, skeletal muscle b. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.692 |
acta1b | hif1aa | ENSDARP00000058628 | ENSDARP00000044281 | Actin alpha 1, skeletal muscle b. | Hypoxia-inducible factor 1 subunit alpha a. | 0.506 |
acta1b | hif1ab | ENSDARP00000058628 | ENSDARP00000004329 | Actin alpha 1, skeletal muscle b. | Hypoxia-inducible factor 1 subunit alpha b. | 0.487 |
acta1b | hif1al | ENSDARP00000058628 | ENSDARP00000132400 | Actin alpha 1, skeletal muscle b. | Hypoxia-inducible factor 1 subunit alpha,-like. | 0.436 |
acta1b | jun | ENSDARP00000058628 | ENSDARP00000063911 | Actin alpha 1, skeletal muscle b. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.737 |
acta1b | mmp9 | ENSDARP00000058628 | ENSDARP00000062844 | Actin alpha 1, skeletal muscle b. | Matrix metallopeptidase 9. | 0.741 |
acta1b | rhoab | ENSDARP00000058628 | ENSDARP00000018377 | Actin alpha 1, skeletal muscle b. | Rho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. | 0.982 |
acta1b | sirt1 | ENSDARP00000058628 | ENSDARP00000088981 | Actin alpha 1, skeletal muscle b. | Sirtuin 1. | 0.555 |
acta1b | smad2 | ENSDARP00000058628 | ENSDARP00000106756 | Actin alpha 1, skeletal muscle b. | Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. | 0.684 |
acta1b | tp53 | ENSDARP00000058628 | ENSDARP00000116736 | Actin alpha 1, skeletal muscle b. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.839 |
acta1b | vegfc | ENSDARP00000058628 | ENSDARP00000092263 | Actin alpha 1, skeletal muscle b. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.541 |
ccnd1 | acta1b | ENSDARP00000140550 | ENSDARP00000058628 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. | Actin alpha 1, skeletal muscle b. | 0.670 |
ccnd1 | cdh2 | ENSDARP00000140550 | ENSDARP00000003949 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. | 0.662 |
ccnd1 | cycsb | ENSDARP00000140550 | ENSDARP00000034555 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.618 |
ccnd1 | hif1aa | ENSDARP00000140550 | ENSDARP00000044281 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. | Hypoxia-inducible factor 1 subunit alpha a. | 0.508 |
ccnd1 | hif1ab | ENSDARP00000140550 | ENSDARP00000004329 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. | Hypoxia-inducible factor 1 subunit alpha b. | 0.523 |
ccnd1 | hif1al | ENSDARP00000140550 | ENSDARP00000132400 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. | Hypoxia-inducible factor 1 subunit alpha,-like. | 0.485 |
ccnd1 | jun | ENSDARP00000140550 | ENSDARP00000063911 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.777 |