STRINGSTRING
caspa caspa add1 add1 maptb maptb X1WCU6_DANRE X1WCU6_DANRE trpv4 trpv4 add2 add2 caspbl caspbl pfn1 pfn1 mertka mertka pfn2 pfn2 add3b add3b egf egf acta1b acta1b pfn2l pfn2l add3a add3a tnfrsf21 tnfrsf21 cfl1 cfl1 rhoab rhoab ripk1l ripk1l sarm1 sarm1 cfl2 cfl2 cfl1l cfl1l rock1 rock1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
caspaCaspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] (383 aa)
add1Adducin 1 (Alpha). (741 aa)
maptbMicrotubule-associated protein. (309 aa)
X1WCU6_DANREProfilin; Belongs to the profilin family. (127 aa)
trpv4Transient receptor potential cation channel, subfamily V, member 4. (856 aa)
add2Adducin 2 (beta). (669 aa)
caspblCaspase b,-like; Belongs to the peptidase C14A family. (409 aa)
pfn1Profilin; Belongs to the profilin family. (141 aa)
mertkaC-mer proto-oncogene tyrosine kinase a. (952 aa)
pfn2Profilin; Belongs to the profilin family. (140 aa)
add3bAdducin 3 (gamma) b. (722 aa)
egfEpidermal growth factor. (1114 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
pfn2lProfilin; Belongs to the profilin family. (139 aa)
add3aAdducin 3 (gamma) a. (672 aa)
tnfrsf21Tumor necrosis factor receptor superfamily, member 21. (637 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
ripk1lReceptor (TNFRSF)-interacting serine-threonine kinase 1,-like. (661 aa)
sarm1NAD(+) hydrolase SARM1; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (By similarity). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (By similarity). Wallerian degeneration is triggerred by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADP [...] (713 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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