STRINGSTRING
irf1a irf1a nfkbiab nfkbiab tnfrsf1a tnfrsf1a irf1b irf1b il1b il1b tlr1 tlr1 alp3 alp3 ticam1 ticam1 alpl alpl tp53 tp53 il10 il10 irf7 irf7 alpi.2 alpi.2 stat1a stat1a b2m b2m saa saa rpl13a rpl13a gapdh gapdh selp selp ccl38a.5 ccl38a.5 gapdhs gapdhs tlr2 tlr2 stat2 stat2 ywhaz ywhaz caspa caspa ifnphi1 ifnphi1 ywhaqb ywhaqb ptgs2a ptgs2a myd88 myd88 alpi.1 alpi.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
irf1aInterferon regulatory factor. (251 aa)
nfkbiabNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (312 aa)
tnfrsf1aTumor necrosis factor receptor superfamily, member 1a. (389 aa)
irf1bInterferon regulatory factor. (287 aa)
il1bInterleukin-1. (284 aa)
tlr1Toll-like receptor 1; Belongs to the Toll-like receptor family. (795 aa)
alp3Alkaline phosphatase. (534 aa)
ticam1Toll-like receptor adaptor molecule 1. (566 aa)
alplAlkaline phosphatase. (561 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
il10Interleukin-10. (180 aa)
irf7Interferon regulatory factor 7. (422 aa)
alpi.2Alkaline phosphatase, intestinal, tandem duplicate 2; Belongs to the alkaline phosphatase family. (530 aa)
stat1aSignal transducer and activator of transcription. (749 aa)
b2mBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (116 aa)
saaSerum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (121 aa)
rpl13aRibosomal protein L13a; Belongs to the universal ribosomal protein uL13 family. (205 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
selpSelectin P. (868 aa)
ccl38a.5C-C motif chemokine. (103 aa)
gapdhsGlyceraldehyde-3-phosphate dehydrogenase 2; Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. (335 aa)
tlr2Toll-like receptor 2. (788 aa)
stat2Signal transducer and activator of transcription. (836 aa)
ywhazTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Belongs to the 14-3-3 family. (244 aa)
caspaCaspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] (383 aa)
ifnphi1Interferon phi 1. (185 aa)
ywhaqbTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (245 aa)
ptgs2aProstaglandin-endoperoxide synthase 2a. (601 aa)
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. (284 aa)
alpi.1Alkaline phosphatase. (532 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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