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hcn4 hcn4 A2BIK1_DANRE A2BIK1_DANRE ano5b ano5b tnni3k tnni3k gnas gnas adcy5 adcy5 glb1 glb1 zgc:158296 zgc:158296 meis1b meis1b popdc2 popdc2 ckmt2a ckmt2a dysf dysf prkacbb prkacbb popdc3 popdc3 bves bves kcnk2a kcnk2a egf egf cav2 cav2 cx43 cx43 ckmb ckmb acta1b acta1b ckmt2b ckmt2b glb1l glb1l kcnk2b kcnk2b ano5a ano5a ntn1b ntn1b ckma ckma pax3a pax3a cav3 cav3 anxa5a anxa5a pde4ba pde4ba ckbb ckbb prkacba prkacba ckmt1 ckmt1 zgc:172270 zgc:172270 anxa5b anxa5b cdh2 cdh2 dmd dmd prkacab prkacab xirp1 xirp1 tjp1a tjp1a cav1 cav1 ctnnb1 ctnnb1 prkacaa prkacaa ckba ckba ntn1a ntn1a ntn2 ntn2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hcn4Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4. (1130 aa)
A2BIK1_DANREBeta-galactosidase. (603 aa)
ano5bAnoctamin. (915 aa)
tnni3kTNNI3-interacting kinase. (835 aa)
gnasGNAS complex locus. (379 aa)
adcy5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1186 aa)
glb1Beta-galactosidase. (676 aa)
zgc:158296Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (171 aa)
meis1bMyeloid ecotropic viral integration 1. (388 aa)
popdc2Popeye domain-containing 2; Important for striated muscle differentiation and cardiac morphogenesis. Is also required for cardiac conduction system development, plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding. (370 aa)
ckmt2aCreatine kinase, mitochondrial 2a (sarcomeric); Belongs to the ATP:guanido phosphotransferase family. (417 aa)
dysfDysferlin, limb girdle muscular dystrophy 2B (autosomal recessive). (2097 aa)
prkacbbProtein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
popdc3Popeye domain-containing 3. (294 aa)
bvesBlood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function. May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)- independent manner. May be involved in epithelial movement during [...] (352 aa)
kcnk2aPotassium channel, subfamily K, member 2a; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
egfEpidermal growth factor. (1114 aa)
cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
cx43Gap junction alpha-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles (By similarity); Belongs to the connexin family. Alpha-type (group II) subfamily. (381 aa)
ckmbCreatine kinase, muscle b; Belongs to the ATP:guanido phosphotransferase family. (380 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
ckmt2bCreatine kinase, mitochondrial 2b (sarcomeric); Belongs to the ATP:guanido phosphotransferase family. (413 aa)
glb1lGalactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family. (629 aa)
kcnk2bPotassium channel, subfamily K, member 2b; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (384 aa)
ano5aAnoctamin. (915 aa)
ntn1bNetrin 1b. (602 aa)
ckmaCreatine kinase, muscle a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
pax3aTranscription factor PAX3. (509 aa)
cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (150 aa)
anxa5aAnnexin. (316 aa)
pde4baPhosphodiesterase. (695 aa)
ckbbBrain-subtype creatine kinase; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
prkacbaProtein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa)
ckmt1Creatine kinase, mitochondrial 1; Belongs to the ATP:guanido phosphotransferase family. (417 aa)
zgc:172270Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (185 aa)
anxa5bAnnexin. (317 aa)
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
dmdDystrophin. (594 aa)
prkacabProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
xirp1Xin actin-binding repeat-containing protein 1; Protects actin filaments from depolymerization. Belongs to the Xin family. (2297 aa)
tjp1aTight junction protein 1a; Belongs to the MAGUK family. (1689 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
prkacaaProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa)
ckbaCreatine kinase, brain a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
ntn1aNetrin-1a. (603 aa)
ntn2Netrin 2. (609 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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