STRINGSTRING
dkk1b dkk1b fbxl17 fbxl17 gli3 gli3 cul3a cul3a shhb shhb smurf2 smurf2 uba1 uba1 kif7 kif7 gsk3ba gsk3ba ptch1 ptch1 prkacba prkacba skp1 skp1 smo smo arih2 arih2 gli2a gli2a smurf1 smurf1 prkacab prkacab usp7 usp7 kctd5a kctd5a ubr3 ubr3 ube2l3a ube2l3a kras kras runx3 runx3 LOC103909792 LOC103909792 uchl5 uchl5 ctnnb1 ctnnb1 atxn3 atxn3 cct2 cct2 prkacaa prkacaa sufu sufu mgrn1a mgrn1a cul3b cul3b ift27 ift27 ulk3 ulk3 numbl numbl spop spop ddb1 ddb1 uba7 uba7 usp8 usp8 shha shha ENSDARP00000125042 ENSDARP00000125042 cul1b cul1b phf19 phf19 lnx1 lnx1 usp48 usp48 gnas gnas numb numb skp2 skp2 kat2b kat2b fbxl7 fbxl7 mpnd mpnd wwp2 wwp2 stk36 stk36 herc4 herc4 rcc1l rcc1l prkacbb prkacbb ihhb ihhb ihha ihha gpr161 gpr161 ptch2 ptch2 stambpa stambpa maea maea
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dkk1bDickkopf WNT-signaling pathway inhibitor 1b. (241 aa)
fbxl17F-box and leucine-rich repeat protein 17. (348 aa)
gli3GLI family zinc finger 3. (1553 aa)
cul3aCullin 3a; Belongs to the cullin family. (774 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
smurf2E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (765 aa)
uba1Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1058 aa)
kif7Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. (1363 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
ptch1Protein patched homolog 1. (1475 aa)
prkacbaProtein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa)
skp1S-phase kinase-associated protein 1A; Belongs to the SKP1 family. (163 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
arih2RBR-type E3 ubiquitin transferase. (492 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
smurf1E3 ubiquitin-protein ligase. (731 aa)
prkacabProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
usp7Ubiquitin-specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1110 aa)
kctd5aPotassium channel tetramerization domain-containing 5a. (224 aa)
ubr3E3 ubiquitin-protein ligase ubr3; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues, leading to their ubiquitination and subsequent degradation (By similarity). Positively regulates hedgehog/shh-signaling pathways that function in eye development, neuronal specification and somite development. Activation of shh up-regulates transcription of ubr3, which in turn promotes hedgehog/shh signaling possibly by controlling negative regulators such as Kif7. (1863 aa)
ube2l3aUbiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family. (172 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
runx3Runt-related transcription factor. (438 aa)
LOC103909792E3 ubiquitin-protein ligase. (903 aa)
uchl5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
atxn3Ataxin 3. (311 aa)
cct2Chaperonin-containing TCP1, subunit 2 (beta); Belongs to the TCP-1 chaperonin family. (286 aa)
prkacaaProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa)
sufuSuppressor of fused homolog. (485 aa)
mgrn1aProbable E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Acts also as a negative regulator of hedgehog signaling. (529 aa)
cul3bCullin 3b; Belongs to the cullin family. (766 aa)
ift27Intraflagellar transport 27 homolog (Chlamydomonas). (186 aa)
ulk3Unc-51-like kinase 3. (407 aa)
numblNUMB-like endocytic adaptor protein. (618 aa)
spopSpeckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. Belongs to the Tdpoz family. (374 aa)
ddb1Damage-specific DNA-binding protein 1. (1142 aa)
uba7Ubiquitin-like modifier-activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (1016 aa)
usp8Ubiquitin-specific peptidase 8; Belongs to the peptidase C19 family. (1067 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
ENSDARP00000125042Patched 1. (120 aa)
cul1bCullin 1b; Belongs to the cullin family. (775 aa)
phf19PHD finger protein 19. (562 aa)
lnx1Ligand of numb-protein X 1. (765 aa)
usp48Ubiquitin-specific peptidase 48; Belongs to the peptidase C19 family. (1092 aa)
gnasGNAS complex locus. (379 aa)
numbNUMB endocytic adaptor protein. (680 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (410 aa)
kat2bHistone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (By similarity). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Also acetylates non- histone proteins. Involved in heart and limb development by mediating acetylation of tbx5. Also acetylates spermidine (By similarity). Together with kat2a, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) ; Bel [...] (796 aa)
fbxl7F-box/LRR-repeat protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the FBXL7 family. (489 aa)
mpndMPN domain-containing protein; Probable protease (By similarity). Acts as a sensor of N(6)- methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (By similarity). (458 aa)
wwp2E3 ubiquitin-protein ligase. (867 aa)
stk36Serine/threonine kinase 36 (fused homolog, Drosophila). (1231 aa)
herc4HECT and RLD domain-containing E3 ubiquitin protein ligase 4. (1052 aa)
rcc1lRCC1-like. (451 aa)
prkacbbProtein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
ihhaHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
gpr161G-protein coupled receptor 161; Key negative regulator of Shh signaling during neural tube development. Recruited to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of gli3 into gli3r and repress the Shh signaling. In presence of shh, it is removed from primary cilia, preventing its activity and allowing activation of the Shh signaling (By similarity). Required in left/right patterning by modulating Ca(2+) levels in the cells surrounding the Kupffer vesicle; [...] (526 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
stambpaSTAM-binding protein-like A; Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes (By similarity). (418 aa)
maeaE3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast maturati [...] (396 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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