STRINGSTRING
myd88 myd88 tlr4bb tlr4bb sod2 sod2 nfe2l2a nfe2l2a jun jun tlr4al tlr4al tlr4ba tlr4ba cdkn1a cdkn1a tp53 tp53 bcl2a bcl2a raf1a-2 raf1a-2 il6 il6 il1b il1b Nox4 Nox4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. (284 aa)
tlr4bbToll-like receptor 4b, duplicate b. (819 aa)
sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
nfe2l2aNuclear factor (Erythroid-derived 2)-like 2. (586 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
tlr4alToll-like receptor 4a, like. (816 aa)
tlr4baToll-like receptor 4b, duplicate a. (787 aa)
cdkn1aCyclin-dependent kinase inhibitor 1A. (154 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
raf1a-2Raf-1 proto-oncogene, serine/threonine kinase a. (186 aa)
il6Interleukin 6 (interferon, beta 2). (231 aa)
il1bInterleukin-1. (284 aa)
Nox4NADPH oxidase 4. (246 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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