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| | gsr | Glutathione reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (425 aa) |
| | casp8 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (476 aa) |
| | tjp1a | Tight junction protein 1a; Belongs to the MAGUK family. (1689 aa) |
| | Nox4 | NADPH oxidase 4. (246 aa) |
| | stat4 | Signal transducer and activator of transcription. (741 aa) |
| | vcam1b | Vascular cell adhesion molecule 1b. (808 aa) |
| | mmel1 | Membrane metallo-endopeptidase-like 1. (765 aa) |
| | pparg | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa) |
| | hist2h3ca1 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | ctsbb | Cathepsin Bb; Belongs to the peptidase C1 family. (327 aa) |
| | nr1h3 | Nuclear receptor subfamily 1, group H, member 3. (441 aa) |
| | ctnnb1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa) |
| | gstp1 | Pi-class glutathione S-transferase; Belongs to the GST superfamily. (208 aa) |
| | lipeb | Lipase, hormone-sensitive b. (872 aa) |
| | gap43 | Growth-associated protein 43. (194 aa) |
| | faslg | Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (268 aa) |
| | nos1 | Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa) |
| | gata4 | GATA-binding protein 4. (352 aa) |
| | ckba | Creatine kinase, brain a; Belongs to the ATP:guanido phosphotransferase family. (381 aa) |
| | ccn2b | Connective tissue growth factor-like protein. (351 aa) |
| | abca1a | ATP-binding cassette, sub-family A (ABC1), member 1A. (2268 aa) |
| | E7FC63_DANRE | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1183 aa) |
| | esco1 | Establishment of sister chromatid cohesion N-acetyltransferase 1. (931 aa) |
| | zgc:162611-2 | Si:dkey-108k21.24. (151 aa) |
| | tgfb1b | Transforming growth factor beta; Belongs to the TGF-beta family. (379 aa) |
| | bcl2a | B-cell leukemia/lymphoma 2. (228 aa) |
| | lipea | Lipase, hormone-sensitive a. (696 aa) |
| | cthl | Cystathionase (cystathionine gamma-lyase),-like. (404 aa) |
| | trpa1a | Transient receptor potential cation channel, subfamily A, member 1a. (1126 aa) |
| | stub1 | STIP1 homology and U-Box-containing protein 1. (287 aa) |
| | cth | Cystathionase (cystathionine gamma-lyase). (404 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa) |
| | trpv1 | Transient receptor potential cation channel, subfamily V, member 1; Belongs to the transient receptor (TC 1.A.4) family. (813 aa) |
| | insb | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa) |
| | Q5RHR2_DANRE | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1187 aa) |
| | caspbl | Caspase b,-like; Belongs to the peptidase C14A family. (409 aa) |
| | stat5b | Signal transducer and activator of transcription. (786 aa) |
| | slc6a3 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (629 aa) |
| | cyp1b1 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (526 aa) |
| | nos2a | Nitric oxide synthase; Produces nitric oxide (NO). (1079 aa) |
| | tlr4ba | Toll-like receptor 4b, duplicate a. (787 aa) |
| | cdh5 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (767 aa) |
| | lectin | Lectin. (152 aa) |
| | mertka | C-mer proto-oncogene tyrosine kinase a. (952 aa) |
| | psmb5 | Proteasome subunit beta. (269 aa) |
| | tlr4al | Toll-like receptor 4a, like. (816 aa) |
| | il10 | Interleukin-10. (180 aa) |
| | tgfb5 | Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa) |
| | stat1b | Signal transducer and activator of transcription. (725 aa) |
| | esco2 | N-acetyltransferase ESCO2; Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together (By similarity). Essential for early development. (609 aa) |
| | casp3a | Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa) |
| | apaf1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). (1261 aa) |
| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa) |
| | tnfb | Tumor necrosis factor b (TNF superfamily, member 2). (242 aa) |
| | bdnf | Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (270 aa) |
| | ckmt1 | Creatine kinase, mitochondrial 1; Belongs to the ATP:guanido phosphotransferase family. (417 aa) |
| | chuk | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (758 aa) |
| | cyba | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (185 aa) |
| | stat1a | Signal transducer and activator of transcription. (749 aa) |
| | gclc | Glutamate-cysteine ligase, catalytic subunit. (631 aa) |
| | rhoab | Rho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa) |
| | stat5a | Signal transducer and activator of transcription. (785 aa) |
| | ckbb | Brain-subtype creatine kinase; Belongs to the ATP:guanido phosphotransferase family. (381 aa) |
| | psmb6 | Proteasome subunit beta. (232 aa) |
| | stat3 | Signal transducer and activator of transcription. (806 aa) |
| | mapk3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa) |
| | sesn2 | Sestrin 2. (444 aa) |
| | ckmt2a | Creatine kinase, mitochondrial 2a (sarcomeric); Belongs to the ATP:guanido phosphotransferase family. (417 aa) |
| | mstnb | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog. (374 aa) |
| | h3f3a-2 | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa) |
| | lipg | Lipase, endothelial. (500 aa) |
| | sirt1 | Sirtuin 1. (710 aa) |
| | zgc:113983 | Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa) |
| | foxp3a | Forkhead box protein. (419 aa) |
| | acaca | Acetyl-CoA carboxylase alpha. (2390 aa) |
| | mif | Macrophage migration inhibitory factor. (115 aa) |
| | serpine1 | Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (392 aa) |
| | ptenb | Phosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa) |
| | ctsba | Cathepsin B, a; Belongs to the peptidase C1 family. (330 aa) |
| | casp3b | Caspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | gsk3bb | Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (419 aa) |
| | zgc:173552 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | cd8a | CD8 antigen, alpha polypeptide. (216 aa) |
| | jun | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa) |
| | ccn2a | Novel protein similar to vertebrate connective tissue growth factor (CTGF). (345 aa) |
| | nfe2l2a | Nuclear factor (Erythroid-derived 2)-like 2. (586 aa) |
| | mmp9 | Matrix metallopeptidase 9. (680 aa) |
| | apoba | Apolipoprotein Ba. (4418 aa) |
| | sod2 | Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa) |
| | selp | Selectin P. (868 aa) |
| | tgfb1a | Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa) |
| | ckmb | Creatine kinase, muscle b; Belongs to the ATP:guanido phosphotransferase family. (380 aa) |
| | cldn1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa) |
| | ckmt2b | Creatine kinase, mitochondrial 2b (sarcomeric); Belongs to the ATP:guanido phosphotransferase family. (413 aa) |
| | hdac3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May play a role in the regulation of the circadian clock in a deacetylase activity-independent manner (By similarity). (428 aa) |
| | ache | Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. (634 aa) |
| | cebpa | CCAAT/enhancer-binding protein. (288 aa) |
| | hdac1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa) |
| | ins | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | cd36 | CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (465 aa) |
| | stat2 | Signal transducer and activator of transcription. (836 aa) |
| | nos2b | Nitric oxide synthase; Produces nitric oxide (NO). (1077 aa) |
| | tgfb3 | Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa) |
| | stat6 | Signal transducer and activator of transcription. (758 aa) |
| | gsk3ba | Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa) |
| | tlr4bb | Toll-like receptor 4b, duplicate b. (819 aa) |
| | caspa | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] (383 aa) |
| | ahr1b | Aryl hydrocarbon receptor 1B. (940 aa) |
| | ckma | Creatine kinase, muscle a; Belongs to the ATP:guanido phosphotransferase family. (381 aa) |
| | hmox1a | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (272 aa) |
| | mb | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (147 aa) |
| | th | Tyrosine hydroxylase. (489 aa) |
| | fosab | V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (349 aa) |
| | mpx | Myeloid-specific peroxidase. (893 aa) |
| | casp9 | Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (436 aa) |
