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barx1 barx1 tfap2a tfap2a sox6 sox6 ripk4 ripk4 kdf1a kdf1a msx1a msx1a irf6 irf6 ctnnb1 ctnnb1 notch1a notch1a wnt5a wnt5a cdh1 cdh1 lrp6 lrp6 bmp5 bmp5 wnt5b wnt5b edar edar axin2 axin2 ldb1b ldb1b gli1 gli1 has1 has1 shha shha ENSDARP00000125042 ENSDARP00000125042 hhat hhat fgfr2 fgfr2 fgf7 fgf7 tbx22 tbx22 foxd2 foxd2 arhgap29b arhgap29b cdkn1a cdkn1a tgfbr1a tgfbr1a nog2 nog2 snai1a snai1a afdna afdna sp7 sp7 lrp5 lrp5 etv5a etv5a mmp13a-2 mmp13a-2 fgf18a fgf18a bcl11ba bcl11ba wnt3 wnt3 fgf9 fgf9 dlx2a dlx2a plekha5 plekha5 dkk2 dkk2 klf4 klf4 grhl3 grhl3 dlx4b dlx4b edn1 edn1 esrp1 esrp1 foxf2b foxf2b dlx6a dlx6a sema3d sema3d mef2ca mef2ca wnt3a wnt3a bmp3 bmp3 nog1 nog1 has3 has3 exoc2 exoc2 casp3b casp3b ptch2 ptch2 fzd2 fzd2 pax9 pax9 nog3 nog3 bmp4 bmp4 snai1b snai1b meox2a meox2a prickle1a prickle1a acta1b acta1b shhb shhb klf17 klf17 wnt9b wnt9b fgf24 fgf24 has2 has2 sema3e sema3e spry2 spry2 fgf10a fgf10a zeb1b zeb1b loxl4 loxl4 foxd1 foxd1 tgfbr2b tgfbr2b vax1 vax1 foxl1 foxl1 tgfb3 tgfb3 ptch1 ptch1 foxf1 foxf1 dlx3b dlx3b fgf8a fgf8a shox2 shox2 bmp7a bmp7a wls wls esrp2 esrp2 bmpr1aa bmpr1aa casp3a casp3a dlx2b dlx2b apaf1 apaf1 gli2a gli2a jag2b jag2b chuk chuk smo smo acvr1l acvr1l
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
barx1Homeobox protein BarH-like 1; Transcription factor, is involved in craniofacial development, and in stomach organogenesis; Belongs to the BAR homeobox family. (248 aa)
tfap2aTranscription factor AP-2 alpha. (450 aa)
sox6SRY-box transcription factor 6. (816 aa)
ripk4Receptor-interacting serine-threonine kinase 4. (835 aa)
kdf1aKeratinocyte differentiation factor 1a. (383 aa)
msx1aMuscle segment homeobox 1a. (233 aa)
irf6Interferon regulatory factor 6. (492 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
cdh1Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa)
lrp6Low density lipoprotein receptor-related protein 6. (935 aa)
bmp5Bone morphogenetic protein 5. (446 aa)
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa)
edarEctodysplasin A receptor. (460 aa)
axin2Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. (812 aa)
ldb1bLIM domain-binding protein 1-A. (411 aa)
gli1GLI family zinc finger 1. (1404 aa)
has1Hyaluronan synthase 1. (571 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
ENSDARP00000125042Patched 1. (120 aa)
hhatHedgehog acyltransferase; Belongs to the membrane-bound acyltransferase family. (508 aa)
fgfr2Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (838 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (180 aa)
tbx22T-box transcription factor 22. (334 aa)
foxd2Forkhead box D2. (369 aa)
arhgap29bRho GTPase-activating protein 29; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42 (By similarity). (1337 aa)
cdkn1aCyclin-dependent kinase inhibitor 1A. (154 aa)
tgfbr1aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (500 aa)
nog2Noggin-2; Inhibitor of bone morphogenetic proteins (BMP) signaling; Belongs to the noggin family. (212 aa)
snai1aSnail family zinc finger 1a. (260 aa)
afdnaAfadin, adherens junction formation factor a. (1976 aa)
sp7Sp7 transcription factor. (528 aa)
lrp5Low density lipoprotein receptor-related protein 5. (1615 aa)
etv5aETS variant transcription factor 5a. (524 aa)
mmp13a-2Matrix metallopeptidase 13a. (475 aa)
fgf18aFibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (208 aa)
bcl11baBAF chromatin-remodeling complex subunit BCL11B a. (208 aa)
wnt3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (142 aa)
dlx2aHomeobox protein Dlx2a; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (274 aa)
plekha5Pleckstrin homology domain-containing, family A member 5. (1238 aa)
dkk2Dickkopf WNT-signaling pathway inhibitor 2. (243 aa)
klf4Kruppel-like factor 4. (340 aa)
grhl3Grainyhead-like transcription factor 3. (557 aa)
dlx4bHomeobox protein Dlx4b; During larvae development, may be important for neurocranium morphogenesis. (254 aa)
edn1Endothelin 1. (188 aa)
esrp1Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity); Belongs to the ESRP family. (714 aa)
foxf2bForkhead box F2b. (429 aa)
dlx6aHomeobox protein Dlx6a. (247 aa)
sema3dSemaphorin-3D; May play a role in the guidance of several axon pathways. (764 aa)
mef2caMyocyte enhancer factor 2ca. (465 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
bmp3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (452 aa)
nog1Noggin-1; Inhibitor of bone morphogenetic proteins (BMP) signaling. May play an important role in the dorsoventral patterning of the embryo; Belongs to the noggin family. (216 aa)
has3Hyaluronan synthase 3. (555 aa)
exoc2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (918 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
fzd2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
pax9Paired box 9. (343 aa)
nog3Noggin-3; May function as an inhibitor of bone morphogenetic proteins (BMP) signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and BMP2/4. Not involved in organizer function or early phases of dorsoventral pattern formation; Belongs to the noggin family. (223 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
snai1bSnail family zinc finger 1b. (256 aa)
meox2aMesenchyme homeobox 2a. (302 aa)
prickle1aPrickle homolog 1a. (793 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
klf17Kruppel-like factor 17. (409 aa)
wnt9bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
fgf24Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
has2Hyaluronan synthase 2. (552 aa)
sema3eSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. (768 aa)
spry2Sprouty RTK-signaling antagonist 2. (301 aa)
fgf10aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
zeb1bZinc finger E-box-binding homeobox 1b. (1078 aa)
loxl4Lysyl oxidase-like 4. (810 aa)
foxd1Forkhead box D1. (343 aa)
tgfbr2bTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (556 aa)
vax1Ventral anterior homeobox 1; Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. (317 aa)
foxl1Forkhead transcription factor. (360 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
ptch1Protein patched homolog 1. (1475 aa)
foxf1Forkhead box protein F1. (380 aa)
dlx3bHomeobox protein Dlx3b; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (269 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
shox2Short stature homeobox 2. (299 aa)
bmp7aBone morphogenetic protein 7a. (432 aa)
wlsWnt ligand secretion mediator. (542 aa)
esrp2Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). (736 aa)
bmpr1aaReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
dlx2bHomeobox protein Dlx2b. (276 aa)
apaf1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). (1261 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
jag2bDelta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1254 aa)
chukInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (758 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
acvr1lReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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