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kdrl kdrl pola1 pola1 fn1a fn1a grna grna lmo2 lmo2 tmem88a tmem88a tnnt2a tnnt2a X1WHF1_DANRE X1WHF1_DANRE flt4 flt4 vegfaa vegfaa notch1a notch1a robo3 robo3 npas4l npas4l nanos1 nanos1 sox7 sox7 egfl7 egfl7 dusp5 dusp5 pbk pbk ets1 ets1 etv2 etv2 pold1 pold1 hist2h2l hist2h2l fli1b fli1b aldh1a2 aldh1a2 fli1a fli1a enpep enpep tal1 tal1 ar ar nanos3 nanos3 jam2b jam2b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kdrlVascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1301 aa)
pola1DNA polymerase. (1468 aa)
fn1aFibronectin 1a. (2480 aa)
grnaGranulin a. (1049 aa)
lmo2Rhombotin-2; Transcription factor that acts synergistically with tal1/scl in primitive and definitive hematopoiesis, and in endothelial development. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hematopoietic induction cues such as gata1, tal1/scl-lmo2-induced haemangioblasts differentiate into endothelial cells. (159 aa)
tmem88aTransmembrane protein 88 a. (219 aa)
tnnt2aTroponin T type 2a (cardiac). (282 aa)
X1WHF1_DANREHistone H2B; Belongs to the histone H2B family. (124 aa)
flt4Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. (1368 aa)
vegfaaVascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. (188 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
robo3Roundabout, axon guidance receptor, homolog 3 (Drosophila). (1420 aa)
npas4lNeuronal PAS domain-containing protein 4-like; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1. (658 aa)
nanos1Nanos homolog 1; Acts as a translational repressor. Can mediate repression affecting different steps in the translation process: cap-driven, IRES- driven, polyadenylated RNAs or nonpolyadenylated RNAs (By similarity). Essential for the development of primordial germ cells (PGCs) by ensuring their proper migration and survival. (228 aa)
sox7SRY-box transcription factor 7. (390 aa)
egfl7EGF-like-domain, multiple 7. (277 aa)
dusp5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (368 aa)
pbkLymphokine-activated killer T-cell-originated protein kinase homolog. (339 aa)
ets1V-ets avian erythroblastosis virus E26 oncogene homolog 1. (266 aa)
etv2ETS variant transcription factor 2. (366 aa)
pold1DNA polymerase. (1105 aa)
hist2h2lHistone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
fli1bFli-1 proto-oncogene, ETS transcription factor b. (467 aa)
aldh1a2Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
fli1aFli-1 proto-oncogene, ETS transcription factor a. (451 aa)
enpepAminopeptidase. (951 aa)
tal1T-cell acute lymphocytic leukemia protein 1 homolog; Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the reg [...] (324 aa)
arAndrogen receptor. (868 aa)
nanos3Nanos homolog 3; Belongs to the nanos family. (159 aa)
jam2bJunctional adhesion molecule 2b. (306 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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