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wnt5b wnt5b gata6 gata6 notch1a notch1a ctnnb1 ctnnb1 gata1a gata1a gli2a gli2a creb3l1 creb3l1 smo smo bmp2a bmp2a bmp7a bmp7a gata3 gata3 cyp11a1 cyp11a1 ptch1 ptch1 tgfb3 tgfb3 tbx3a tbx3a gata5 gata5 tbx20 tbx20 tbx5a tbx5a cyp17a1 cyp17a1 rarga rarga gli3 gli3 tgfb1a tgfb1a jun jun bmp4 bmp4 ptch2 ptch2 wnt1 wnt1 foxh1 foxh1 raraa raraa ihhb ihhb gata2a gata2a lhcgr lhcgr wnt3a wnt3a fshr fshr tgfb5 tgfb5 elk1 elk1 slco4a1 slco4a1 myca myca wnt3 wnt3 cyp1b1 cyp1b1 bmp2b bmp2b tbx2b tbx2b fshb fshb cyp19a1a cyp19a1a slco2a1 slco2a1 miox miox tgfb1b tgfb1b ENSDARP00000125042 ENSDARP00000125042 shha shha gli1 gli1 gata4 gata4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa)
gata6GATA-binding protein 6. (501 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
gata1aGATA-binding protein 1a. (418 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
creb3l1cAMP-responsive element-binding protein 3-like 1. (526 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
bmp2aBone morphogenetic protein 2a. (386 aa)
bmp7aBone morphogenetic protein 7a. (432 aa)
gata3Transcription factor GATA-3. (438 aa)
cyp11a1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (509 aa)
ptch1Protein patched homolog 1. (1475 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
tbx3aT-box transcription factor 3a. (689 aa)
gata5Transcription factor gata5. (383 aa)
tbx20T-box transcription factor TBX20; Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors. (446 aa)
tbx5aT-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa)
cyp17a1Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (519 aa)
rargaRetinoic acid receptor gamma-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and for the development of pharyngeal arches; Belongs to the nuclear hormone receptor family. NR1 subfamily. (499 aa)
gli3GLI family zinc finger 3. (1553 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
wnt1Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Involved in neurogenesis. Performs a partially redundant function with wnt10b in the formation of the midbrain-hindbrain boundary (MHB) organizer. In the hindbrain, mediates lateral inhibition of boundary cell specification, probably via up-regulation of proneural and Delta gene expression in non-boundary cells; localized expression of wnt1 in boundary cells is maintained vi [...] (370 aa)
foxh1Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa)
raraaRetinoic acid receptor alpha-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain patterning; Belongs to the nuclear hormone receptor family. NR1 subfamily. (444 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
gata2aGATA-binding protein 2a. (456 aa)
lhcgrLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (708 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
fshrThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (668 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
elk1ETS transcription factor ELK1. (521 aa)
slco4a1Solute carrier organic anion transporter family member. (742 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
wnt3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
cyp1b1Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (526 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
tbx2bT-box transcription factor TBX2b; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation. (687 aa)
fshbFollicle-stimulating hormone beta subunit. (130 aa)
cyp19a1aAromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (517 aa)
slco2a1Solute carrier organic anion transporter family member. (625 aa)
mioxInositol oxygenase; Belongs to the myo-inositol oxygenase family. (283 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
ENSDARP00000125042Patched 1. (120 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
gli1GLI family zinc finger 1. (1404 aa)
gata4GATA-binding protein 4. (352 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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