STRINGSTRING
ephb4a ephb4a kras kras Reln Reln notch1a notch1a faslg faslg itgam itgam flt4 flt4 fgf2 fgf2 tgfb1b tgfb1b vegfd vegfd thbs1b thbs1b taz taz araf araf tp53 tp53 lyve1a lyve1a il13 il13 tgfb5 tgfb5 vegfc vegfc egf egf s1pr1 s1pr1 tgfb1a tgfb1a nras nras tek tek rasa1a rasa1a ifnphi1 ifnphi1 tgfb3 tgfb3 flt1 flt1 mmp2 mmp2 lyve1b lyve1b thbs1a thbs1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ephb4aEphrin type-B receptor 4a; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and [...] (987 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
RelnReelin domain-containing protein. (259 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
faslgFas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (268 aa)
itgamIntegrin, alpha M (complement component 3 receptor 3 subunit); Belongs to the integrin alpha chain family. (780 aa)
flt4Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. (1368 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
vegfdVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (272 aa)
thbs1bThrombospondin 1b. (1171 aa)
tazTafazzin family protein; Belongs to the taffazin family. (262 aa)
arafA-Raf proto-oncogene, serine/threonine kinase. (604 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
lyve1aLymphatic vessel endothelial hyaluronic receptor 1a. (328 aa)
il13Interleukin 4/13A. (157 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
vegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa)
egfEpidermal growth factor. (1114 aa)
s1pr1Sphingosine 1-phosphate receptor 1; G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. (362 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
nrasGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (188 aa)
tekTyrosine-protein kinase receptor Tie-2; Tyrosine-protein kinase that acts as cell-surface receptor for angiopoietins and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Can activate or inhibit angiogenesis, depending on the context. Angiopoietin signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors (By similarity). (1116 aa)
rasa1aRAS p21 protein activator (GTPase-activating protein) 1a. (1010 aa)
ifnphi1Interferon phi 1. (185 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
flt1Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1272 aa)
mmp2Matrix metalloproteinase 2. (657 aa)
lyve1bLymphatic vessel endothelial hyaluronic receptor 1b. (355 aa)
thbs1aThrombospondin 1a. (795 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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