STRINGSTRING
mertka mertka tnfb tnfb stat1a stat1a ifnphi1 ifnphi1 ctss2.2 ctss2.2 caspa caspa ldlra ldlra cetp cetp cd36 cd36 ctss1 ctss1 klf17 klf17 acta1b acta1b apoeb apoeb ccl38a.5 ccl38a.5 cxcr4b cxcr4b mmp9 mmp9 ctsd ctsd stab1 stab1 f13a1b f13a1b irf7 irf7 ptprc ptprc klf4 klf4 ctss2.1 ctss2.1 lgals3a lgals3a lectin lectin il13 il13 pcsk9 pcsk9 isg15 isg15 caspbl caspbl cd40 cd40 cd9a cd9a F13A1 F13A1 or126-1 or126-1 irf5 irf5 il1b il1b ccr2-2 ccr2-2 ccr2 ccr2 csf1ra csf1ra lyve1b lyve1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mertkaC-mer proto-oncogene tyrosine kinase a. (952 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
stat1aSignal transducer and activator of transcription. (749 aa)
ifnphi1Interferon phi 1. (185 aa)
ctss2.2Cathepsin S, ortholog 2, tandem duplicate 2; Belongs to the peptidase C1 family. (330 aa)
caspaCaspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] (383 aa)
ldlraLow density lipoprotein receptor a. (911 aa)
cetpCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa)
cd36CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (465 aa)
ctss1Cathepsin S, ortholog 1; Belongs to the peptidase C1 family. (328 aa)
klf17Kruppel-like factor 17. (409 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
apoebApolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. (281 aa)
ccl38a.5C-C motif chemokine. (103 aa)
cxcr4bChemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa)
mmp9Matrix metallopeptidase 9. (680 aa)
ctsdCtsd protein; Belongs to the peptidase A1 family. (398 aa)
stab1Stabilin 1. (2553 aa)
f13a1bCoagulation factor XIII, A1 polypeptide b. (742 aa)
irf7Interferon regulatory factor 7. (422 aa)
ptprcProtein tyrosine phosphatase receptor type C. (1130 aa)
klf4Kruppel-like factor 4. (340 aa)
ctss2.1Cathepsin S, ortholog2, tandem duplicate 1; Belongs to the peptidase C1 family. (330 aa)
lgals3aGalectin. (332 aa)
lectinLectin. (152 aa)
il13Interleukin 4/13A. (157 aa)
pcsk9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (667 aa)
isg15ISG15 ubiquitin-like modifier. (157 aa)
caspblCaspase b,-like; Belongs to the peptidase C14A family. (409 aa)
cd40CD40 molecule, TNF receptor superfamily member 5. (286 aa)
cd9aTetraspanin. (228 aa)
F13A1Coagulation factor XIII A chain. (508 aa)
or126-1Olfactory receptor. (309 aa)
irf5Interferon regulatory factor 5. (516 aa)
il1bInterleukin-1. (284 aa)
ccr2-2Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
ccr2Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (354 aa)
csf1raMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa)
lyve1bLymphatic vessel endothelial hyaluronic receptor 1b. (355 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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