Patched 1.

G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition.

Patched 1.

Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...]

Patched 1.

Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development; Belongs to the hedgehog family.

Patched 1.

GLI family zinc finger 1.

Patched 1.

GLI family zinc finger 2a.

Patched 1.

GLI family zinc finger 3.

Patched 1.

Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.

Patched 1.

Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.

Patched 1.

Indian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation.

Patched 1.

Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]

Patched 1.

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.

Patched 1.

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily.

Patched 1.

Protein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily.

Patched 1.

Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.

Patched 1.

Secreted frizzled-related protein 5.

Patched 1.

Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).

Patched 1.

Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes.

Patched 1.

Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.

Patched 1.

Suppressor of fused homolog.

Patched 1.

Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis.