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dkk1b | Dickkopf WNT-signaling pathway inhibitor 1b. (241 aa) | ||||
tfap2a | Transcription factor AP-2 alpha. (450 aa) | ||||
pitx1 | Homeobox protein. (285 aa) | ||||
TCF4 | Transcription factor 4. (536 aa) | ||||
cav1 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa) | ||||
ccnd1 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa) | ||||
b4galt1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1. (286 aa) | ||||
ctnnb1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa) | ||||
notch1a | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa) | ||||
wnt5a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa) | ||||
axin1 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa) | ||||
prkacaa | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa) | ||||
foxo1a | Forkhead box protein O1-A; Transcriptional regulator of cell cycle arrest required for cellular stress responses (By similarity). May be involved in regulating cellular homeostasis in the eye. (652 aa) | ||||
wnt5b | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa) | ||||
sufu | Suppressor of fused homolog. (485 aa) | ||||
hif1al | Hypoxia-inducible factor 1 subunit alpha,-like. (626 aa) | ||||
ets2 | V-ets avian erythroblastosis virus E26 oncogene homolog 2. (439 aa) | ||||
gli1 | GLI family zinc finger 1. (1404 aa) | ||||
ndp | Norrin cystine knot growth factor NDP. (138 aa) | ||||
shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) | ||||
ENSDARP00000125042 | Patched 1. (120 aa) | ||||
tgfb1b | Transforming growth factor beta; Belongs to the TGF-beta family. (379 aa) | ||||
abcb5 | ATP-binding cassette, sub-family B (MDR/TAP), member 5. (1338 aa) | ||||
nck1b | Cytoplasmic protein. (381 aa) | ||||
jag1a | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1253 aa) | ||||
bcl2a | B-cell leukemia/lymphoma 2. (228 aa) | ||||
lef1 | Lymphocyte enhancer binding factor 1 Lef1. (365 aa) | ||||
cd44a | CD44 molecule (Indian blood group) a. (392 aa) | ||||
lrp5 | Low density lipoprotein receptor-related protein 5. (1615 aa) | ||||
nppa | Natriuretic peptide A. (139 aa) | ||||
birc5a | Baculoviral IAP repeat-containing 5a. (190 aa) | ||||
myca | Transcriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa) | ||||
dkk2 | Dickkopf WNT-signaling pathway inhibitor 2. (243 aa) | ||||
smad4a | Mothers against decapentaplegic homolog. (547 aa) | ||||
tgfb5 | Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa) | ||||
stat3 | Signal transducer and activator of transcription. (806 aa) | ||||
sox2 | Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). (315 aa) | ||||
hey1 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. (317 aa) | ||||
nck2a | Cytoplasmic protein. (403 aa) | ||||
pitx3 | Pituitary homeobox 3; Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons (By similarity). Required for lens and retinal development and for pituitary pre-placode formation and cell specification; Belongs to the paired homeobox family. Bicoid subfamily. (293 aa) | ||||
sirt1 | Sirtuin 1. (710 aa) | ||||
prkacbb | Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa) | ||||
ihhb | Indian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa) | ||||
ihha | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa) | ||||
casp3b | Caspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa) | ||||
ptch2 | Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa) | ||||
gsk3bb | Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (419 aa) | ||||
prkacab | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa) | ||||
hif1ab | Hypoxia-inducible factor 1 subunit alpha b. (777 aa) | ||||
casp3a | Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa) | ||||
jag1b | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa) | ||||
pofut1 | Protein O-fucosyltransferase 1. (395 aa) | ||||
ybx1 | Y-box-binding protein 1; DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation. Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C). Promotes mRNA stabilization: acts by binding to m5C- containing mRNAs and recruiting pabpc1a, thereby preventing mRNA decay. Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation. Also [...] (309 aa) | ||||
gli2a | GLI family zinc finger 2a. (1439 aa) | ||||
smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) | ||||
stat1a | Signal transducer and activator of transcription. (749 aa) | ||||
dkk1a | Dickkopf WNT-signaling pathway inhibitor 1a. (256 aa) | ||||
ccna1 | Cyclin A1; Belongs to the cyclin family. (391 aa) | ||||
prkacba | Protein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa) | ||||
ptch1 | Protein patched homolog 1. (1475 aa) | ||||
tgfb3 | Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa) | ||||
gsk3ba | Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa) | ||||
bcl2l1 | Bcl-XL-like protein 1. (238 aa) | ||||
ets1 | V-ets avian erythroblastosis virus E26 oncogene homolog 1. (266 aa) | ||||
fosab | V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (349 aa) | ||||
hif1aa | Hypoxia-inducible factor 1 subunit alpha a. (717 aa) | ||||
tle3a | Transducin-like enhancer protein 3-A; Transcriptional corepressor that binds to a number of transcription factors. Enhances the transcriptional repression activity of pnx; Belongs to the WD repeat Groucho/TLE family. (776 aa) | ||||
pitx2 | Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa) | ||||
dhh | Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development; Belongs to the hedgehog family. (447 aa) | ||||
b4galt5 | Beta-1,4-galactosyltransferase 5; Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (By similarity). Required for proper patterning of the dorsoventral axis during embryogenesis through the regulation of BMP signaling. Plays a role in proteoglycan glycosylation that is required for BMP-dependent specification of the dorsoventral axis ; Belongs to the glycosyltransferase 7 family. (381 aa) | ||||
shhb | Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa) | ||||
sfrp5 | Secreted frizzled-related protein 5. (310 aa) | ||||
snai2 | Snail homolog 2 (Drosophila). (257 aa) | ||||
gli3 | GLI family zinc finger 3. (1553 aa) | ||||
tgfb1a | Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa) | ||||
nfe2l2a | Nuclear factor (Erythroid-derived 2)-like 2. (586 aa) | ||||
nck2b | Cytoplasmic protein. (380 aa) | ||||
pou5f3 | POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa) | ||||
notch3 | Notch receptor 3. (2468 aa) |