STRINGSTRING
dkk1b dkk1b tfap2a tfap2a pitx1 pitx1 TCF4 TCF4 cav1 cav1 ccnd1 ccnd1 b4galt1 b4galt1 ctnnb1 ctnnb1 notch1a notch1a wnt5a wnt5a axin1 axin1 prkacaa prkacaa foxo1a foxo1a wnt5b wnt5b sufu sufu hif1al hif1al ets2 ets2 gli1 gli1 ndp ndp shha shha ENSDARP00000125042 ENSDARP00000125042 tgfb1b tgfb1b abcb5 abcb5 nck1b nck1b jag1a jag1a bcl2a bcl2a lef1 lef1 cd44a cd44a lrp5 lrp5 nppa nppa birc5a birc5a myca myca dkk2 dkk2 smad4a smad4a tgfb5 tgfb5 stat3 stat3 sox2 sox2 hey1 hey1 nck2a nck2a pitx3 pitx3 sirt1 sirt1 prkacbb prkacbb ihhb ihhb ihha ihha casp3b casp3b ptch2 ptch2 gsk3bb gsk3bb prkacab prkacab hif1ab hif1ab casp3a casp3a jag1b jag1b pofut1 pofut1 ybx1 ybx1 gli2a gli2a smo smo stat1a stat1a dkk1a dkk1a ccna1 ccna1 prkacba prkacba ptch1 ptch1 tgfb3 tgfb3 gsk3ba gsk3ba bcl2l1 bcl2l1 ets1 ets1 fosab fosab hif1aa hif1aa tle3a tle3a pitx2 pitx2 dhh dhh b4galt5 b4galt5 shhb shhb sfrp5 sfrp5 snai2 snai2 gli3 gli3 tgfb1a tgfb1a nfe2l2a nfe2l2a nck2b nck2b pou5f3 pou5f3 notch3 notch3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dkk1bDickkopf WNT-signaling pathway inhibitor 1b. (241 aa)
tfap2aTranscription factor AP-2 alpha. (450 aa)
pitx1Homeobox protein. (285 aa)
TCF4Transcription factor 4. (536 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
ccnd1G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa)
b4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1. (286 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
axin1Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa)
prkacaaProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa)
foxo1aForkhead box protein O1-A; Transcriptional regulator of cell cycle arrest required for cellular stress responses (By similarity). May be involved in regulating cellular homeostasis in the eye. (652 aa)
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa)
sufuSuppressor of fused homolog. (485 aa)
hif1alHypoxia-inducible factor 1 subunit alpha,-like. (626 aa)
ets2V-ets avian erythroblastosis virus E26 oncogene homolog 2. (439 aa)
gli1GLI family zinc finger 1. (1404 aa)
ndpNorrin cystine knot growth factor NDP. (138 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
ENSDARP00000125042Patched 1. (120 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
abcb5ATP-binding cassette, sub-family B (MDR/TAP), member 5. (1338 aa)
nck1bCytoplasmic protein. (381 aa)
jag1aProtein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1253 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
lef1Lymphocyte enhancer binding factor 1 Lef1. (365 aa)
cd44aCD44 molecule (Indian blood group) a. (392 aa)
lrp5Low density lipoprotein receptor-related protein 5. (1615 aa)
nppaNatriuretic peptide A. (139 aa)
birc5aBaculoviral IAP repeat-containing 5a. (190 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
dkk2Dickkopf WNT-signaling pathway inhibitor 2. (243 aa)
smad4aMothers against decapentaplegic homolog. (547 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
stat3Signal transducer and activator of transcription. (806 aa)
sox2Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). (315 aa)
hey1Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. (317 aa)
nck2aCytoplasmic protein. (403 aa)
pitx3Pituitary homeobox 3; Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons (By similarity). Required for lens and retinal development and for pituitary pre-placode formation and cell specification; Belongs to the paired homeobox family. Bicoid subfamily. (293 aa)
sirt1Sirtuin 1. (710 aa)
prkacbbProtein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
ihhaHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
gsk3bbGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (419 aa)
prkacabProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
hif1abHypoxia-inducible factor 1 subunit alpha b. (777 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
jag1bProtein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa)
pofut1Protein O-fucosyltransferase 1. (395 aa)
ybx1Y-box-binding protein 1; DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation. Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C). Promotes mRNA stabilization: acts by binding to m5C- containing mRNAs and recruiting pabpc1a, thereby preventing mRNA decay. Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation. Also [...] (309 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
stat1aSignal transducer and activator of transcription. (749 aa)
dkk1aDickkopf WNT-signaling pathway inhibitor 1a. (256 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (391 aa)
prkacbaProtein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa)
ptch1Protein patched homolog 1. (1475 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
bcl2l1Bcl-XL-like protein 1. (238 aa)
ets1V-ets avian erythroblastosis virus E26 oncogene homolog 1. (266 aa)
fosabV-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (349 aa)
hif1aaHypoxia-inducible factor 1 subunit alpha a. (717 aa)
tle3aTransducin-like enhancer protein 3-A; Transcriptional corepressor that binds to a number of transcription factors. Enhances the transcriptional repression activity of pnx; Belongs to the WD repeat Groucho/TLE family. (776 aa)
pitx2Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa)
dhhDesert hedgehog protein; Intercellular signal essential for a variety of patterning events during development; Belongs to the hedgehog family. (447 aa)
b4galt5Beta-1,4-galactosyltransferase 5; Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (By similarity). Required for proper patterning of the dorsoventral axis during embryogenesis through the regulation of BMP signaling. Plays a role in proteoglycan glycosylation that is required for BMP-dependent specification of the dorsoventral axis ; Belongs to the glycosyltransferase 7 family. (381 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
sfrp5Secreted frizzled-related protein 5. (310 aa)
snai2Snail homolog 2 (Drosophila). (257 aa)
gli3GLI family zinc finger 3. (1553 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
nfe2l2aNuclear factor (Erythroid-derived 2)-like 2. (586 aa)
nck2bCytoplasmic protein. (380 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
notch3Notch receptor 3. (2468 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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