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meis1b meis1b rdh10a rdh10a dhrs3a dhrs3a olig2 olig2 shhb shhb aldh1a3 aldh1a3 pitx2 pitx2 rarga rarga cyp26a1 cyp26a1 aldh3a2a aldh3a2a tbx5a tbx5a fgf8a fgf8a tbx6 tbx6 rdh10b rdh10b rxrab rxrab tbxtb tbxtb aldh3b2 aldh3b2 aldh3a1 aldh3a1 tbxta tbxta pax6a pax6a rdh20 rdh20 shha shha ncor1 ncor1 hnf1ba hnf1ba tbx16l tbx16l rars1 rars1 aldh3a2b aldh3a2b hoxb1a hoxb1a cyp26b1 cyp26b1 dkk2 dkk2 cdx4 cdx4 aldh3b1 aldh3b1 aldh1a2 aldh1a2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
meis1bMyeloid ecotropic viral integration 1. (388 aa)
rdh10aRetinol dehydrogenase 10-A; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (339 aa)
dhrs3aDehydrogenase/reductase (SDR family) member 3a. (302 aa)
olig2Oligodendrocyte lineage transcription factor 2. (273 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
aldh1a3Retinaldehyde dehydrogenase family 1 subfamily A3; Belongs to the aldehyde dehydrogenase family. (513 aa)
pitx2Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa)
rargaRetinoic acid receptor gamma-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and for the development of pharyngeal arches; Belongs to the nuclear hormone receptor family. NR1 subfamily. (499 aa)
cyp26a1Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa)
aldh3a2aAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (488 aa)
tbx5aT-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
tbx6T-box transcription factor TBX6; T-box transcription factor involved in the development of paraxial mesoderm. (874 aa)
rdh10bRetinol dehydrogenase 10-B; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (336 aa)
rxrabRetinoic acid receptor RXR-alpha-B; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (By similarity). The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (By similarity). The high affinity ligand for rxrs is 9- cis retinoic acid (By similarity). [...] (379 aa)
tbxtbT-box transcription factor Tb. (427 aa)
aldh3b2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (502 aa)
aldh3a1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa)
tbxtaT-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa)
pax6aPaired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa)
rdh20Retinol dehydrogenase 20; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
ncor1Nuclear receptor corepressor 1. (2398 aa)
hnf1baHepatocyte nuclear factor 1-beta-A; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of rhombomere r5/r6 gene expression in the hindbrain. (555 aa)
tbx16lT-box transcription factor TBX6L; Probable transcriptional regulator involved in developmental processes. (488 aa)
rars1Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (661 aa)
aldh3a2bAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (490 aa)
hoxb1aHomeobox protein Hox-B1a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (316 aa)
cyp26b1Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. (511 aa)
dkk2Dickkopf WNT-signaling pathway inhibitor 2. (243 aa)
cdx4Caudal type homeo box transcription factor 4. (270 aa)
aldh3b1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (473 aa)
aldh1a2Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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