STRINGSTRING
il6r il6r il1b il1b mpp3a mpp3a asxl1 asxl1 stub1 stub1 tp53 tp53 mtor mtor tet2 tet2 stat3 stat3 chek2 chek2 u2af1 u2af1 casp3a casp3a tnfb tnfb ppm1da ppm1da myd88 myd88 ezh2 ezh2 idh1 idh1 mycn mycn ptpn11a ptpn11a srsf2a srsf2a idh2 idh2 nr4a1 nr4a1 cebpa cebpa socs3a socs3a casp3b casp3b txnipa txnipa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
il6rInterleukin 6 receptor. (604 aa)
il1bInterleukin-1. (284 aa)
mpp3aMembrane protein, palmitoylated 3a (MAGUK p55 subfamily member 3); Belongs to the MAGUK family. (591 aa)
asxl1ASXL transcriptional regulator 1. (1619 aa)
stub1STIP1 homology and U-Box-containing protein 1. (287 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
tet2Tet methylcytosine dioxygenase 2. (1715 aa)
stat3Signal transducer and activator of transcription. (806 aa)
chek2Checkpoint kinase 2. (503 aa)
u2af1U2 small nuclear RNA auxiliary factor 1. (250 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
ppm1daProtein phosphatase 1D magnesium-dependent, delta isoform. (535 aa)
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. (284 aa)
ezh2Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily. (760 aa)
idh1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (429 aa)
mycnN-myc protein; May function as a transcription factor. (503 aa)
ptpn11aTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
srsf2aSerine and arginine-rich-splicing factor 2a. (225 aa)
idh2Isocitrate dehydrogenase (NADP(+)) 2. (225 aa)
nr4a1Nuclear receptor subfamily 4, group A, member 1. (574 aa)
cebpaCCAAT/enhancer-binding protein. (288 aa)
socs3aSuppressor of cytokine-signaling 3a. (207 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
txnipaThioredoxin-interacting protein a. (400 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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