STRINGSTRING
gas1b gas1b klf2b klf2b gas1a gas1a nrg1 nrg1 gli1 gli1 pkd1b pkd1b lrp2b lrp2b Rac1l Rac1l shha shha ENSDARP00000125042 ENSDARP00000125042 lrp13 lrp13 A2BIK1_DANRE A2BIK1_DANRE tmem67 tmem67 kif3a kif3a glb1 glb1 rac1b rac1b boc boc rac1a rac1a arl13b arl13b ihhb ihhb ihha ihha ptch2 ptch2 klf2a klf2a ift172 ift172 cx43 cx43 gli3 gli3 shhb shhb dhh dhh nfatc1 nfatc1 notch1b notch1b glb1l glb1l ift88 ift88 pkd2 pkd2 ptch1 ptch1 rhoab rhoab smo smo efnb2a efnb2a erbb2 erbb2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gas1bGrowth arrest-specific 1b. (263 aa)
klf2bKruppel-like factor 2b. (363 aa)
gas1aGrowth arrest-specific 1a. (270 aa)
nrg1Neuregulin 1. (730 aa)
gli1GLI family zinc finger 1. (1404 aa)
pkd1bPolycystic kidney disease 1b. (3827 aa)
lrp2bLow density lipoprotein receptor-related protein 2b. (4602 aa)
Rac1lSi:ch211-1f22.1. (192 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
ENSDARP00000125042Patched 1. (120 aa)
lrp13Low-density lipoprotein receptor-related-protein 13. (1355 aa)
A2BIK1_DANREBeta-galactosidase. (603 aa)
tmem67Transmembrane protein 67. (982 aa)
kif3aKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (701 aa)
glb1Beta-galactosidase. (676 aa)
rac1bRas-related C3 botulinum toxin substrate 1-like protein. (192 aa)
bocBOC cell adhesion-associated, oncogene-regulated. (1032 aa)
rac1aRas-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (192 aa)
arl13bADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] (407 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
ihhaHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
klf2aKruppel-like factor 2a. (380 aa)
ift172Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. (1745 aa)
cx43Gap junction alpha-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles (By similarity); Belongs to the connexin family. Alpha-type (group II) subfamily. (381 aa)
gli3GLI family zinc finger 3. (1553 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
dhhDesert hedgehog protein; Intercellular signal essential for a variety of patterning events during development; Belongs to the hedgehog family. (447 aa)
nfatc1Nuclear factor of-activated T cells 1. (867 aa)
notch1bNotch receptor 1b. (2465 aa)
glb1lGalactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family. (629 aa)
ift88Intraflagellar transport 88 homolog. (824 aa)
pkd2Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as non-selective, voltage-gated cation channel (By similarity). Required for normal oscillation of Ca(2+) levels within cilia; these oscillations of the intraciliary Ca(2+) levels can trigger cytoplasmic Ca(2+) signaling cascades. May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (By simila [...] (904 aa)
ptch1Protein patched homolog 1. (1475 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
efnb2aEphrin-B2a; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with ephb4 may play a central role in heart morph [...] (332 aa)
erbb2Receptor protein-tyrosine kinase. (1275 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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