(18 nodes) (2022) The Non-Receptor Protein Tyrosine Phosphatase PTPN6 Mediates a Positive Regulatory Approach From the Interferon Regulatory Factor to the JAKSTAT Pathway in Litopenaeus vannamei. network (Danio rerio)

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Your Input:
	stat2	Signal transducer and activator of transcription. (836 aa)
	stat6	Signal transducer and activator of transcription. (758 aa)
	bcl2l1	Bcl-XL-like protein 1. (238 aa)
	jak1	Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures. (1153 aa)
	jak3	Tyrosine-protein kinase. (1103 aa)
	stat1a	Signal transducer and activator of transcription. (749 aa)
	eef1a1l1	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa)
	ptpn6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
	ptprt	Protein tyrosine phosphatase receptor type T. (1442 aa)
	slc44a4	Choline transporter-like protein 4; Choline transporter that seems to play a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury; Belongs to the CTL (choline transporter-like) family. (703 aa)
	socs1b	Suppressor of cytokine-signaling 1b. (193 aa)
	ptprk	Protein tyrosine phosphatase receptor type K. (1163 aa)
	stat3	Signal transducer and activator of transcription. (806 aa)
	src	Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
	ptprt-2	Protein tyrosine phosphatase receptor type T. (632 aa)
	ptpn11a	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	egf	Epidermal growth factor. (1114 aa)
	socs1a	Suppressor of cytokine-signaling 1a. (201 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
bcl2l1	egf	ENSDARP00000027919	ENSDARP00000069126	Bcl-XL-like protein 1.	Epidermal growth factor.	0.467
bcl2l1	src	ENSDARP00000027919	ENSDARP00000093618	Bcl-XL-like protein 1.	Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...]	0.559
bcl2l1	stat1a	ENSDARP00000027919	ENSDARP00000015753	Bcl-XL-like protein 1.	Signal transducer and activator of transcription.	0.502
bcl2l1	stat3	ENSDARP00000027919	ENSDARP00000095292	Bcl-XL-like protein 1.	Signal transducer and activator of transcription.	0.767
bcl2l1	stat6	ENSDARP00000027919	ENSDARP00000026606	Bcl-XL-like protein 1.	Signal transducer and activator of transcription.	0.441
egf	bcl2l1	ENSDARP00000069126	ENSDARP00000027919	Epidermal growth factor.	Bcl-XL-like protein 1.	0.467
egf	ptpn11a	ENSDARP00000069126	ENSDARP00000076040	Epidermal growth factor.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.499
egf	ptprk	ENSDARP00000069126	ENSDARP00000117401	Epidermal growth factor.	Protein tyrosine phosphatase receptor type K.	0.475
egf	src	ENSDARP00000069126	ENSDARP00000093618	Epidermal growth factor.	Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...]	0.894
egf	stat1a	ENSDARP00000069126	ENSDARP00000015753	Epidermal growth factor.	Signal transducer and activator of transcription.	0.553
egf	stat2	ENSDARP00000069126	ENSDARP00000050681	Epidermal growth factor.	Signal transducer and activator of transcription.	0.463
egf	stat3	ENSDARP00000069126	ENSDARP00000095292	Epidermal growth factor.	Signal transducer and activator of transcription.	0.811
egf	stat6	ENSDARP00000069126	ENSDARP00000026606	Epidermal growth factor.	Signal transducer and activator of transcription.	0.487
jak1	jak3	ENSDARP00000037399	ENSDARP00000049468	Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures.	Tyrosine-protein kinase.	0.822
jak1	ptpn11a	ENSDARP00000037399	ENSDARP00000076040	Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.547
jak1	ptpn6	ENSDARP00000037399	ENSDARP00000148161	Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.644
jak1	socs1a	ENSDARP00000037399	ENSDARP00000055536	Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures.	Suppressor of cytokine-signaling 1a.	0.927
jak1	stat1a	ENSDARP00000037399	ENSDARP00000015753	Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures.	Signal transducer and activator of transcription.	0.996
jak1	stat2	ENSDARP00000037399	ENSDARP00000050681	Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures.	Signal transducer and activator of transcription.	0.990
jak1	stat3	ENSDARP00000037399	ENSDARP00000095292	Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures.	Signal transducer and activator of transcription.	0.980

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