STRINGSTRING
il1b il1b apoea apoea eif2ak2 eif2ak2 txnipb txnipb gpx9 gpx9 gpx7 gpx7 tgfb1b tgfb1b bcl2a bcl2a caspbl caspbl xbp1 xbp1 il10 il10 tgfb5 tgfb5 arg1 arg1 gpx4a gpx4a cdk5 cdk5 casp3b casp3b gsk3bb gsk3bb bace2 bace2 jun jun gpx3 gpx3 nfe2l2a nfe2l2a sod2 sod2 tgfb1a tgfb1a apoeb apoeb arg2 arg2 ache ache txnipa txnipa gsr gsr hmox1a hmox1a cycsb cycsb caspa caspa gsk3ba gsk3ba tgfb3 tgfb3 gpx1a gpx1a pon1 pon1 gpx8 gpx8 gpx1b gpx1b bdnf bdnf tnfb tnfb atf6 atf6 parp1 parp1 gpx4b gpx4b casp3a casp3a atf4a atf4a pparg pparg
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
il1bInterleukin-1. (284 aa)
apoeaApolipoprotein Ea. (269 aa)
eif2ak2Eukaryotic translation initiation factor 2-alpha kinase 2. (682 aa)
txnipbThioredoxin-interacting protein b. (379 aa)
gpx9Glutathione peroxidase; Belongs to the glutathione peroxidase family. (140 aa)
gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
caspblCaspase b,-like; Belongs to the peptidase C14A family. (409 aa)
xbp1Transcription factor Treb5. (263 aa)
il10Interleukin-10. (180 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
arg1Arginase. (341 aa)
gpx4aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
cdk5Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
gsk3bbGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (419 aa)
bace2Zgc:103530 protein; Belongs to the peptidase A1 family. (372 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
gpx3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (222 aa)
nfe2l2aNuclear factor (Erythroid-derived 2)-like 2. (586 aa)
sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
apoebApolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. (281 aa)
arg2Arginase. (347 aa)
acheAcetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. (634 aa)
txnipaThioredoxin-interacting protein a. (400 aa)
gsrGlutathione reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (425 aa)
hmox1aHeme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (272 aa)
cycsbCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (104 aa)
caspaCaspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] (383 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
gpx1aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (191 aa)
pon1Zgc:91887 protein. (356 aa)
gpx8Probable glutathione peroxidase 8; Belongs to the glutathione peroxidase family. (210 aa)
gpx1bGlutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (270 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
atf6Activating transcription factor 6. (653 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
gpx4bGlutathione peroxidase; Belongs to the glutathione peroxidase family. (170 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
atf4aCyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. May play a role in the regulation of the circadian clock (By similarity). (339 aa)
ppargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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