STRINGSTRING
cib2 cib2 pdhb pdhb rho rho vim vim adgrv1 adgrv1 cdh23 cdh23 dlg4 dlg4 anks4b anks4b acta1b acta1b zgc:110796 zgc:110796 ush2a ush2a msi1 msi1 arl13b arl13b lectin lectin ush1c ush1c cdh23-2 cdh23-2 msi2a msi2a DOCK4 DOCK4 pxdn pxdn jam2a jam2a itgam itgam ctnnb1 ctnnb1 myo7aa myo7aa ush1gb ush1gb tjp1a tjp1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cib2Calcium and integrin-binding family member 2. (187 aa)
pdhbPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
rhoRhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (354 aa)
vimVimentin; Belongs to the intermediate filament family. (455 aa)
adgrv1Adhesion G-protein coupled receptor V1; Receptor that may have an important role in the development of the sensory nervous system. (6198 aa)
cdh23Cadherin-related 23. (2883 aa)
dlg4Disks large homolog 4; Plays a role in synapse assembly and function. Plays a role in synaptic plasticity. (707 aa)
anks4bAnkyrin repeat and sterile alpha motif domain-containing 4B. (422 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
zgc:110796Zgc:110796. (94 aa)
ush2aUsher syndrome 2A (autosomal recessive, mild). (5236 aa)
msi1Musashi RNA-binding protein 1. (297 aa)
arl13bADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] (407 aa)
lectinLectin. (152 aa)
ush1cUsher syndrome 1C (Autosomal recessive, severe). (548 aa)
cdh23-2Cadherin-related 23. (436 aa)
msi2aMusashi homolog 2a (Drosophila). (388 aa)
DOCK4Si:dkey-81e3.1; Belongs to the DOCK family. (1925 aa)
pxdnPeroxidasin. (1460 aa)
jam2aJunctional adhesion molecule 2A; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam3b on neighboring myocytes. Belongs to the immunoglobulin superfamily. (307 aa)
itgamIntegrin, alpha M (complement component 3 receptor 3 subunit); Belongs to the integrin alpha chain family. (780 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
myo7aaMyosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2190 aa)
ush1gbUsher syndrome 1Gb (autosomal recessive). (488 aa)
tjp1aTight junction protein 1a; Belongs to the MAGUK family. (1689 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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