STRINGSTRING
hk2 hk2 sirt6 sirt6 acat1 acat1 hif1al hif1al atg5 atg5 gzm3.3 gzm3.3 ccr7 ccr7 sqstm1 sqstm1 gzm3.4 gzm3.4 havcr2 havcr2 stat5b stat5b xbp1 xbp1 il13 il13 becn1 becn1 myca myca hdac5 hdac5 il10 il10 tdo2a tdo2a stat3 stat3 atg12 atg12 pik3c3 pik3c3 ppargc1a ppargc1a srebf1 srebf1 foxp3a foxp3a ptenb ptenb gzm3 gzm3 gzm3.2 gzm3.2 jun jun arg2 arg2 mitfa mitfa ido1 ido1 cd36 cd36 stat2 stat2 igf1rb igf1rb hif1aa hif1aa ahr1b ahr1b tdo2b tdo2b hif1ab hif1ab slc16a3 slc16a3 tnfb tnfb mycb mycb mapk8b mapk8b stat1a stat1a igf1ra igf1ra gnaq gnaq mitfb mitfb stat5a stat5a stat1b stat1b stat6 stat6 tfeb tfeb TCF4 TCF4 ccl34a.4 ccl34a.4 stat4 stat4 pparg pparg ctnnb1 ctnnb1 hdac4 hdac4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hk2Hexokinase 2. (919 aa)
sirt6Sirtuin (Silent mating type information regulation 2 homolog) 6 (S. cerevisiae). (354 aa)
acat1Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...] (420 aa)
hif1alHypoxia-inducible factor 1 subunit alpha,-like. (626 aa)
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
gzm3.3Granzyme 3, tandem duplicate 3; Belongs to the peptidase S1 family. (257 aa)
ccr7Chemokine (C-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (385 aa)
sqstm1Sequestosome 1. (452 aa)
gzm3.4Granzyme 3, tandem duplicate 4. (251 aa)
havcr2Hepatitis A virus cellular receptor 2. (231 aa)
stat5bSignal transducer and activator of transcription. (786 aa)
xbp1Transcription factor Treb5. (263 aa)
il13Interleukin 4/13A. (157 aa)
becn1Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] (447 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1128 aa)
il10Interleukin-10. (180 aa)
tdo2aTryptophan 2,3-dioxygenase A; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
stat3Signal transducer and activator of transcription. (806 aa)
atg12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (120 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa)
ppargc1aPeroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (859 aa)
srebf1Sterol regulatory element-binding transcription factor 1. (879 aa)
foxp3aForkhead box protein. (419 aa)
ptenbPhosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa)
gzm3Granzyme 3, tandem duplicate 1; Belongs to the peptidase S1 family. (253 aa)
gzm3.2Granzyme 3, tandem duplicate 2. (249 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
arg2Arginase. (347 aa)
mitfaMicrophthalmia-associated transcription factor a. (412 aa)
ido1Indoleamine 2,3-dioxygenase 1. (435 aa)
cd36CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (465 aa)
stat2Signal transducer and activator of transcription. (836 aa)
igf1rbTyrosine-protein kinase receptor. (1380 aa)
hif1aaHypoxia-inducible factor 1 subunit alpha a. (717 aa)
ahr1bAryl hydrocarbon receptor 1B. (940 aa)
tdo2bTryptophan 2,3-dioxygenase B; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (407 aa)
hif1abHypoxia-inducible factor 1 subunit alpha b. (777 aa)
slc16a3Solute carrier family 16 member 3. (508 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
mycbTranscriptional regulator Myc-B; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (396 aa)
mapk8bMitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock. (384 aa)
stat1aSignal transducer and activator of transcription. (749 aa)
igf1raTyrosine-protein kinase receptor. (1405 aa)
gnaqGuanine nucleotide-binding protein (G protein), q polypeptide. (359 aa)
mitfbMicrophthalmia-associated transcription factor b. (500 aa)
stat5aSignal transducer and activator of transcription. (785 aa)
stat1bSignal transducer and activator of transcription. (725 aa)
stat6Signal transducer and activator of transcription. (758 aa)
tfebTranscription factor EB. (493 aa)
TCF4Transcription factor 4. (536 aa)
ccl34a.4Chemokine (C-C motif) ligand 34a, duplicate 4. (138 aa)
stat4Signal transducer and activator of transcription. (741 aa)
ppargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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