STRINGSTRING
ace ace ace2 ace2 nos2a nos2a insb insb tgfb1b tgfb1b ckma ckma ckba ckba nos1 nos1 fgf21 fgf21 mmel1 mmel1 vcam1b vcam1b nr3c2 nr3c2 h2ax h2ax nos2b nos2b ins ins ckmt2b ckmt2b ckmb ckmb tgfb1a tgfb1a ren ren cybb cybb nox1 nox1 slc9a1b slc9a1b sirt1 sirt1 ckmt2a ckmt2a tnfb tnfb ckmt1 ckmt1 ckbb ckbb cycsb cycsb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
aceAngiotensin-converting enzyme. (1324 aa)
ace2Angiotensin-converting enzyme. (818 aa)
nos2aNitric oxide synthase; Produces nitric oxide (NO). (1079 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
ckmaCreatine kinase, muscle a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
ckbaCreatine kinase, brain a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
fgf21Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. (194 aa)
mmel1Membrane metallo-endopeptidase-like 1. (765 aa)
vcam1bVascular cell adhesion molecule 1b. (808 aa)
nr3c2Nuclear receptor subfamily 3, group C, member 2. (970 aa)
h2axHistone H2AX; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low dos [...] (142 aa)
nos2bNitric oxide synthase; Produces nitric oxide (NO). (1077 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
ckmt2bCreatine kinase, mitochondrial 2b (sarcomeric); Belongs to the ATP:guanido phosphotransferase family. (413 aa)
ckmbCreatine kinase, muscle b; Belongs to the ATP:guanido phosphotransferase family. (380 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
renRenin; Belongs to the peptidase A1 family. (395 aa)
cybbCytochrome b-245, beta polypeptide (chronic granulomatous disease). (565 aa)
nox1NADPH oxidase 1. (564 aa)
slc9a1bSodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (653 aa)
sirt1Sirtuin 1. (710 aa)
ckmt2aCreatine kinase, mitochondrial 2a (sarcomeric); Belongs to the ATP:guanido phosphotransferase family. (417 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
ckmt1Creatine kinase, mitochondrial 1; Belongs to the ATP:guanido phosphotransferase family. (417 aa)
ckbbBrain-subtype creatine kinase; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
cycsbCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (104 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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