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actn3b actn3b gata4 gata4 insb insb znf219 znf219 tnnc2 tnnc2 col2a1a col2a1a srfa srfa ins ins atp2a1 atp2a1 tnni2a.4 tnni2a.4 tbx5a tbx5a wt1a wt1a zbtb20 zbtb20 nkx2.5 nkx2.5 sox9a sox9a col1a1a col1a1a sp3a sp3a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
actn3bActinin alpha 3b. (898 aa)
gata4GATA-binding protein 4. (352 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
znf219Zinc finger protein 219; Transcriptional regulator. Recognizes and binds to the core DNA sequence motif 5'-GGGGG-3'. Binds to the col2a1a promoter and activates col2a1a expression. Binds to the sncgb promoter and activates sncgb expression, as part of a complex with sox9a. (1095 aa)
tnnc2Fast skeletal muscle troponin C. (160 aa)
col2a1aCollagen, type II, alpha 1a. (1491 aa)
srfaSerum response factor a. (539 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
atp2a1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1005 aa)
tnni2a.4Troponin I type 2a (skeletal, fast), tandem duplicate 4. (176 aa)
tbx5aT-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa)
wt1aWT1 transcription factor a. (419 aa)
zbtb20Zinc finger and BTB domain-containing 20. (687 aa)
nkx2.5NK2 homeobox 5. (314 aa)
sox9aHMG box transcription factor Sox9a. (462 aa)
col1a1aCollagen, type I, alpha 1a. (1447 aa)
sp3aSp3a transcription factor. (679 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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