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actn3b actn3b RYR2 RYR2 tln2b tln2b pxna pxna cav1 cav1 sptbn1 sptbn1 csrp3 csrp3 dnm2b dnm2b dnm2a dnm2a ryr2b ryr2b tln2a tln2a vegfaa vegfaa tln1 tln1 sptbn5 sptbn5 syne1b syne1b sptbn4a sptbn4a syne1a syne1a insb insb sptb sptb zyx zyx tmod4 tmod4 sun1 sun1 ttn.1 ttn.1 vcla vcla mtor mtor tmod1 tmod1 piezo1 piezo1 vclb vclb zgc:158296 zgc:158296 src src mstnb mstnb LOC558044 LOC558044 pxnb pxnb klf8 klf8 ptpn11a ptpn11a ilk ilk kcnk2a kcnk2a cav2 cav2 cftr cftr acta1b acta1b ins ins kcnk2b kcnk2b smad3a smad3a ptk2ab ptk2ab myf6 myf6 cav3 cav3 tcap tcap tmod2 tmod2 zgc:172270 zgc:172270 myog myog myod1 myod1 cfl2 cfl2 dmd dmd
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
actn3bActinin alpha 3b. (898 aa)
RYR2Uncharacterized protein. (4478 aa)
tln2bTalin 2b. (1537 aa)
pxnaPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (532 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
sptbn1Spectrin beta chain; Belongs to the spectrin family. (2272 aa)
csrp3Cysteine and glycine-rich protein 3 (cardiac LIM protein). (193 aa)
dnm2bDynamin 2b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (432 aa)
dnm2aDynamin 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (860 aa)
ryr2bRyanodine receptor 2b (cardiac). (4878 aa)
tln2aTalin 2a. (2543 aa)
vegfaaVascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. (188 aa)
tln1Talin 1. (2544 aa)
sptbn5Spectrin, beta, non-erythrocytic 5. (4140 aa)
syne1bSpectrin repeat-containing, nuclear envelope 1b. (8710 aa)
sptbn4aSpectrin, beta, non-erythrocytic 4a. (1412 aa)
syne1aSpectrin repeat-containing, nuclear envelope 1a. (8697 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
sptbSpectrin beta chain; Belongs to the spectrin family. (2357 aa)
zyxZyxin. (608 aa)
tmod4Tropomodulin 4 (Muscle). (343 aa)
sun1Sad1 and UNC84 domain-containing 1. (997 aa)
ttn.1Titin, tandem duplicate 1. (29152 aa)
vclaVinculin a. (1131 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
tmod1Tropomodulin 1. (356 aa)
piezo1Piezo-type mechanosensitive ion channel component. (2436 aa)
vclbVinculin b. (987 aa)
zgc:158296Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (171 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
mstnbGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog. (374 aa)
LOC558044Spectrin beta chain; Belongs to the spectrin family. (2391 aa)
pxnbPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (525 aa)
klf8Kruppel-like factor 8. (343 aa)
ptpn11aTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
ilkIntegrin-linked kinase. (452 aa)
kcnk2aPotassium channel, subfamily K, member 2a; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
cftrCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1485 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
kcnk2bPotassium channel, subfamily K, member 2b; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (384 aa)
smad3aMothers against decapentaplegic homolog. (425 aa)
ptk2abProtein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1050 aa)
myf6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (239 aa)
cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (150 aa)
tcapTitin-cap (telethonin). (179 aa)
tmod2Tropomodulin 2. (344 aa)
zgc:172270Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (185 aa)
myogMyogenin. (256 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
dmdDystrophin. (594 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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