STRINGSTRING
col1a1a col1a1a alp3 alp3 p4ha3 p4ha3 alpi.1 alpi.1 atf6 atf6 p4ha2 p4ha2 atf4a atf4a eif2ak2 eif2ak2 casp3a casp3a crtap crtap gapdh gapdh htt htt alpi.2 alpi.2 casp3b casp3b colgalt1-2 colgalt1-2 zgc:152670 zgc:152670 ctrl ctrl p3h1 p3h1 p4ha1b p4ha1b becn1 becn1 xbp1 xbp1 alpl alpl atg5 atg5 colgalt1 colgalt1 pxdn pxdn
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
col1a1aCollagen, type I, alpha 1a. (1447 aa)
alp3Alkaline phosphatase. (534 aa)
p4ha3Prolyl 4-hydroxylase, alpha polypeptide III. (590 aa)
alpi.1Alkaline phosphatase. (532 aa)
atf6Activating transcription factor 6. (653 aa)
p4ha2Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2. (536 aa)
atf4aCyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. May play a role in the regulation of the circadian clock (By similarity). (339 aa)
eif2ak2Eukaryotic translation initiation factor 2-alpha kinase 2. (682 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
crtapCartilage-associated protein. (396 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
httHuntingtin. (3121 aa)
alpi.2Alkaline phosphatase, intestinal, tandem duplicate 2; Belongs to the alkaline phosphatase family. (530 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
colgalt1-2Procollagen galactosyltransferase 1; Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the formation of collagen triple helix. (604 aa)
zgc:152670Zgc:152670. (490 aa)
ctrlChymotrypsin-like; Belongs to the peptidase S1 family. (261 aa)
p3h1Prolyl 3-hydroxylase 1. (829 aa)
p4ha1bProcollagen-proline, 2-oxoglutarate 4-dioxygenase (Proline 4-hydroxylase), alpha polypeptide I. (536 aa)
becn1Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] (447 aa)
xbp1Transcription factor Treb5. (263 aa)
alplAlkaline phosphatase. (561 aa)
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
colgalt1Procollagen galactosyltransferase 1. (618 aa)
pxdnPeroxidasin. (1460 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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