STRINGSTRING
tlx3b tlx3b wnt7ba wnt7ba sst2 sst2 nkx2.2a nkx2.2a irx3a irx3a nkx2.4b nkx2.4b pax7a pax7a pax6a pax6a dbx2 dbx2 calr3a calr3a shha shha onecutl onecutl nfia nfia pvalb7 pvalb7 crha crha casz1 casz1 foxd2 foxd2 calb1 calb1 vsx1 vsx1 foxg1a foxg1a fezf2 fezf2 calr calr wnt3a wnt3a hmga2 hmga2 ikzf1 ikzf1 id2a id2a bmp4 bmp4 foxp1b foxp1b jun jun gsx2 gsx2 oxt oxt calb2a calb2a olig2 olig2 emx1 emx1 calb2b calb2b gsx1 gsx1 foxd1 foxd1 crhb crhb nkx6.1 nkx6.1 sim1a sim1a foxl1 foxl1 nkx2.1 nkx2.1 foxn4 foxn4 kcnj2a kcnj2a emx3 emx3 fgf8a fgf8a sim1b sim1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tlx3bT cell leukemia homeobox 3b. (300 aa)
wnt7baProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
sst2Somatostatin 2. (107 aa)
nkx2.2aHomeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). (273 aa)
irx3aIroquois 3 homeobox protein. (454 aa)
nkx2.4bNK2 homeobox 1a. (307 aa)
pax7aTranscription factor PAX7C. (507 aa)
pax6aPaired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa)
dbx2Homeobox domain-containing protein. (121 aa)
calr3aCalreticulin. (418 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
onecutlOne cut domain family member. (450 aa)
nfiaNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (507 aa)
pvalb7Parvalbumin-7; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). (109 aa)
crhaCorticotropin-releasing hormone a. (155 aa)
casz1Castor zinc finger 1. (1644 aa)
foxd2Forkhead box D2. (369 aa)
calb1Calbindin 1. (260 aa)
vsx1Visual system homeobox 1; May be involved in maintenance as well as cellular differentiation of retinal interneurons, such as bipolar cells. May play a role in establishing interneuronal cell classes in nonsensory as well as sensory systems; Belongs to the paired homeobox family. (340 aa)
foxg1aForkhead box G1a. (420 aa)
fezf2Fez family zinc finger protein 2; Transcription repressor. Component of the regulatory cascade that controls the development of dopaminergic (DA) and serotonergic (5HT) neurons. (438 aa)
calrCalreticulin. (417 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
hmga2High mobility group AT-hook 2. (110 aa)
ikzf1IKAROS family zinc finger 1 (Ikaros). (526 aa)
id2aInhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a. (137 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
foxp1bForkhead box protein P1-B; Transcriptional repressor. (659 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
gsx2GS homeobox 2. (242 aa)
oxtOxytocin; Belongs to the vasopressin/oxytocin family. (154 aa)
calb2aCalbindin 2, like. (271 aa)
olig2Oligodendrocyte lineage transcription factor 2. (273 aa)
emx1Homeobox protein EMX1; May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system; Belongs to the EMX homeobox family. (231 aa)
calb2bCalbindin 2b. (269 aa)
gsx1Genetic screen homeobox 1 protein. (243 aa)
foxd1Forkhead box D1. (343 aa)
crhbCorticotropin-releasing hormone b. (162 aa)
nkx6.1NK6 homeobox 1. (312 aa)
sim1aSingle-minded homolog 1-A; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. (745 aa)
foxl1Forkhead transcription factor. (360 aa)
nkx2.1NK2 homeobox 1b. (346 aa)
foxn4Forkhead box protein N4; Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the [...] (550 aa)
kcnj2aPotassium inwardly rectifying channel subfamily J member 2a. (427 aa)
emx3Empty spiracles homeobox 3. (233 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
sim1bSIM bHLH transcription factor 1b. (586 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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