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psmd7 psmd7 atp5pb atp5pb rpl3 rpl3 ndufa10 ndufa10 rpl5a rpl5a psma6a psma6a ndufa9a ndufa9a eif3d eif3d ndufs5 ndufs5 psmb1 psmb1 uqcrb uqcrb psmb3 psmb3 skp1 skp1 acp5a acp5a eif3i eif3i rpl27 rpl27 fads2 fads2 idh1 idh1 eif3m eif3m mrpl24 mrpl24 got2b got2b idh2 idh2 elovl5 elovl5 atp5fa1 atp5fa1 rps27.1 rps27.1 sem1 sem1 psmc1a psmc1a fntb fntb uqcrq uqcrq ndufb10 ndufb10 acox1 acox1 hadh hadh ndufs4 ndufs4 aldh9a1b aldh9a1b ndufa6 ndufa6 gapdhs gapdhs got2a got2a mdh2 mdh2 gapdh gapdh psmc1b psmc1b psma4 psma4 eif2s2 eif2s2 pklr pklr eef1g eef1g ndufab1a ndufab1a zmpste24 zmpste24 ndufa5 ndufa5 psmd6 psmd6 ndufb5 ndufb5 ndufb8 ndufb8 psmc5 psmc5 ndufs7 ndufs7 psmb5 psmb5 rps26 rps26 rpl5b rpl5b uqcrc1 uqcrc1 rpl22 rpl22 psmb7 psmb7 dao.1 dao.1 acadm acadm psmb4 psmb4 rpl10 rpl10 sdhc sdhc cpt2 cpt2 rpsa rpsa cox5aa cox5aa scd scd si:dkey-16i5.8 si:dkey-16i5.8 got1 got1 atp5pd atp5pd cox7c cox7c uchl5 uchl5 taldo1 taldo1 rps3 rps3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmd7Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog). (327 aa)
atp5pbATP synthase peripheral stalk-membrane subunit b. (252 aa)
rpl3Ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family. (403 aa)
ndufa10NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (355 aa)
rpl5aRibosomal protein L5a. (297 aa)
psma6aProteasome subunit alpha type. (246 aa)
ndufa9aNADH:ubiquinone oxidoreductase subunit A9a. (380 aa)
eif3dEukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs. (552 aa)
ndufs5NADH dehydrogenase (Ubiquinone) Fe-S protein 5. (106 aa)
psmb1Proteasome subunit beta. (237 aa)
uqcrbCytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family. (111 aa)
psmb3Proteasome subunit beta. (205 aa)
skp1S-phase kinase-associated protein 1A; Belongs to the SKP1 family. (163 aa)
acp5aTartrate-resistant acid phosphatase type 5. (339 aa)
eif3iEukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (325 aa)
rpl2760S ribosomal protein L27; Component of the large ribosomal subunit. (136 aa)
fads2Fatty acid desaturase 2; Fatty acid desaturase with both Delta(5) and Delta(6) activities. Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n- 6) and alpha-linolenic acid (ALA) (18:3n-3). (444 aa)
idh1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (429 aa)
eif3mEukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (375 aa)
mrpl24Probable 39S ribosomal protein L24, mitochondrial; Belongs to the universal ribosomal protein uL24 family. (216 aa)
got2bAspartate aminotransferase. (428 aa)
idh2Isocitrate dehydrogenase (NADP(+)) 2. (225 aa)
elovl5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (291 aa)
atp5fa1ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (551 aa)
rps27.140S ribosomal protein S27. (84 aa)
sem1SEM1 26S proteasome complex subunit. (92 aa)
psmc1aProteasome (Prosome, macropain) 26S subunit, ATPase, 1a; Belongs to the AAA ATPase family. (440 aa)
fntbProtein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (419 aa)
uqcrqUbiquinol-cytochrome c reductase, complex III subunit VII. (82 aa)
ndufb10NADH:ubiquinone oxidoreductase subunit B10. (170 aa)
acox1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
hadhHydroxyacyl-Coenzyme A dehydrogenase. (309 aa)
ndufs4NADH dehydrogenase (Ubiquinone) Fe-S protein 4, (NADH-coenzyme Q reductase). (168 aa)
aldh9a1b4-trimethylaminobutyraldehyde dehydrogenase B; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. (518 aa)
ndufa6NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (128 aa)
gapdhsGlyceraldehyde-3-phosphate dehydrogenase 2; Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. (335 aa)
got2aAspartate aminotransferase. (428 aa)
mdh2Malate dehydrogenase. (337 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
psmc1bProteasome (Prosome, macropain) 26S subunit, ATPase, 1b; Belongs to the AAA ATPase family. (440 aa)
psma4Proteasome subunit alpha type. (261 aa)
eif2s2Eukaryotic translation initiation factor 2, subunit 2 beta. (327 aa)
pklrPyruvate kinase; Belongs to the pyruvate kinase family. (538 aa)
eef1gElongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components. (442 aa)
ndufab1aAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (155 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (468 aa)
ndufa5NADH:ubiquinone oxidoreductase subunit A5. (116 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (386 aa)
ndufb5NADH dehydrogenase (Ubiquinone) 1 beta subcomplex 5. (186 aa)
ndufb8NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (188 aa)
psmc5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
ndufs7NADH:ubiquinone oxidoreductase core subunit S7; Belongs to the complex I 20 kDa subunit family. (217 aa)
psmb5Proteasome subunit beta. (269 aa)
rps2640S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (115 aa)
rpl5bRibosomal protein L5b. (296 aa)
uqcrc1Ubiquinol-cytochrome c reductase core protein 1. (503 aa)
rpl22Ribosomal protein L22. (141 aa)
psmb7Proteasome subunit beta. (277 aa)
dao.1D-amino-acid oxidase, tandem duplicate 1. (348 aa)
acadmAcyl-CoA dehydrogenase medium chain. (426 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (256 aa)
rpl1060S ribosomal protein L10; Component of the large ribosomal subunit (Probable). Plays a role in the formation of actively translating ribosomes. Plays a role in the embryonic brain development. (215 aa)
sdhcSuccinate dehydrogenase complex, subunit C, integral membrane protein. (169 aa)
cpt2Carnitine O-palmitoyltransferase 2, mitochondrial. (669 aa)
rpsa40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Belongs to the universal ribosomal protein uS2 family. (308 aa)
cox5aaCytochrome c oxidase subunit 5Aa. (141 aa)
scdStearoyl-CoA desaturase (delta-9-desaturase); Belongs to the fatty acid desaturase type 1 family. (326 aa)
si:dkey-16i5.8Si:dkey-16i5.8. (155 aa)
got1Aspartate aminotransferase. (410 aa)
atp5pdATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (161 aa)
cox7cCytochrome c oxidase, subunit VIIc. (63 aa)
uchl5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
taldo1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (286 aa)
rps3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (245 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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