STRINGSTRING
cdh2 cdh2 ehmt2 ehmt2 egfra egfra rock2a rock2a tgfb1b tgfb1b abi1a abi1a lef1 lef1 sp1 sp1 cdk1 cdk1 bmi1a bmi1a fbxl5 fbxl5 vcla vcla twist2 twist2 lectin lectin brd4 brd4 vclb vclb smad4a smad4a tgfb5 tgfb5 stat3 stat3 src src vaspb vaspb ar ar cops5 cops5 ilk ilk ptenb ptenb jun jun yy1a yy1a tgfb1a tgfb1a acta1b acta1b snai2 snai2 arg2 arg2 hdac3 hdac3 hdac1 hdac1 zeb1b zeb1b smad3a smad3a lama5 lama5 twist1a twist1a celf1 celf1 mapk1 mapk1 suv39h1a suv39h1a tgfb3 tgfb3 ezh2 ezh2 mapkapk2a mapkapk2a rhoab rhoab mapkapk2b mapkapk2b vim vim dnmt1 dnmt1 twist3 twist3 lama4 lama4 ythdf1 ythdf1 vaspa vaspa rock1 rock1 ctnnb1 ctnnb1 notch1a notch1a gata6 gata6 rock2b rock2b cdh1 cdh1 e2f4 e2f4 lamb1a lamb1a ets2 ets2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
ehmt2Euchromatic histone-lysine N-methyltransferase 2. (1167 aa)
egfraEpidermal growth factor receptor precursor. (625 aa)
rock2aRho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1375 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
abi1aAbl-interactor 1a. (483 aa)
lef1Lymphocyte enhancer binding factor 1 Lef1. (365 aa)
sp1Sp1 transcription factor. (594 aa)
cdk1Cell division control protein 2; Belongs to the protein kinase superfamily. (302 aa)
bmi1aPolycomb complex protein BMI-1-A; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2. (322 aa)
fbxl5F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of ireb2/irp2. Upon high iron and oxygen level, it specifically recognizes and binds ireb2/irp2, promoting its ubiquitination and degradation by the proteasome (By similarity). (679 aa)
vclaVinculin a. (1131 aa)
twist2Twist2. (163 aa)
lectinLectin. (152 aa)
brd4Bromodomain-containing protein 4; Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and rec [...] (1444 aa)
vclbVinculin b. (987 aa)
smad4aMothers against decapentaplegic homolog. (547 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
stat3Signal transducer and activator of transcription. (806 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
vaspbVasodilator-stimulated phosphoprotein b. (445 aa)
arAndrogen receptor. (868 aa)
cops5COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex; Belon [...] (334 aa)
ilkIntegrin-linked kinase. (452 aa)
ptenbPhosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
yy1aYY1 transcription factor a. (357 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
snai2Snail homolog 2 (Drosophila). (257 aa)
arg2Arginase. (347 aa)
hdac3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May play a role in the regulation of the circadian clock in a deacetylase activity-independent manner (By similarity). (428 aa)
hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa)
zeb1bZinc finger E-box-binding homeobox 1b. (1078 aa)
smad3aMothers against decapentaplegic homolog. (425 aa)
lama5Laminin, alpha 5. (3664 aa)
twist1aTwist family bHLH transcription factor 1a. (171 aa)
celf1CUGBP Elav-like family member 1; RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in mRNA translation activation and stability (By similarity). Involved in the regulation of muscle-specific splicing of alpha actinin pre-mRNAs via the binding to the UR-repeat element (URE) at the branch point of the non-muscle (NM) exon; Belongs to the CELF/BRUNOL family. (534 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
suv39h1aHistone-lysine N-methyltransferase SUV39H1-A; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric [...] (411 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
ezh2Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily. (760 aa)
mapkapk2aMitogen-activated protein kinase-activated protein kinase 2a; Belongs to the protein kinase superfamily. (382 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
mapkapk2bMAPK-activated protein kinase 2b; Belongs to the protein kinase superfamily. (397 aa)
vimVimentin; Belongs to the intermediate filament family. (455 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1500 aa)
twist3Twist3. (199 aa)
lama4Laminin, alpha 4. (1871 aa)
ythdf1YTH N(6)-methyladenosine RNA-binding protein 1. (614 aa)
vaspaVasodilator-stimulated phosphoprotein a. (412 aa)
rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
gata6GATA-binding protein 6. (501 aa)
rock2bRho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1401 aa)
cdh1Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa)
e2f4E2F transcription factor 4. (404 aa)
lamb1aLaminin, beta 1a. (1785 aa)
ets2V-ets avian erythroblastosis virus E26 oncogene homolog 2. (439 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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