STRINGSTRING
stat1b stat1b sirt7 sirt7 stat4 stat4 pparg pparg ccr2 ccr2 ccr2-2 ccr2-2 casp22 casp22 vdra vdra nlrp1 nlrp1 tlr18 tlr18 nod2 nod2 tyk2 tyk2 caspbl caspbl stat5b stat5b lectin lectin il10 il10 casp8 casp8 stat3 stat3 rab1aa rab1aa ido1 ido1 tlr2 tlr2 sirt3 sirt3 cd36 cd36 stat2 stat2 rab1ab rab1ab ptk2ab ptk2ab jak1 jak1 caspa caspa ifnphi1 ifnphi1 stat6 stat6 stat5a stat5a myd88 myd88 stat1a stat1a zgc:171927 zgc:171927
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
stat1bSignal transducer and activator of transcription. (725 aa)
sirt7Sirtuin 7. (405 aa)
stat4Signal transducer and activator of transcription. (741 aa)
ppargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa)
ccr2Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (354 aa)
ccr2-2Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
casp22Caspase 22, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (376 aa)
vdraVitamin D3 receptor A. (234 aa)
nlrp1NACHT, LRR and PYD domains-containing protein 1 homolog; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, which activates caspases caspa and caspb leading to processing and secretion of proinflammatory cytokines. Required for the sequential recruitment of pro-caspa and pro-caspb to the inflammasome, which promotes activation of the caspases and the caspa/b-catalyzed il1b maturation and secretion in the e [...] (1192 aa)
tlr18Toll-like receptor 18. (854 aa)
nod2Nucleotide-binding oligomerization domain-containing 2. (980 aa)
tyk2Tyrosine-protein kinase. (1165 aa)
caspblCaspase b,-like; Belongs to the peptidase C14A family. (409 aa)
stat5bSignal transducer and activator of transcription. (786 aa)
lectinLectin. (152 aa)
il10Interleukin-10. (180 aa)
casp8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (476 aa)
stat3Signal transducer and activator of transcription. (806 aa)
rab1aaRAB1A, member RAS oncogene family a. (201 aa)
ido1Indoleamine 2,3-dioxygenase 1. (435 aa)
tlr2Toll-like receptor 2. (788 aa)
sirt3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (357 aa)
cd36CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (465 aa)
stat2Signal transducer and activator of transcription. (836 aa)
rab1abRAB1A, member RAS oncogene family b. (201 aa)
ptk2abProtein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1050 aa)
jak1Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures. (1153 aa)
caspaCaspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] (383 aa)
ifnphi1Interferon phi 1. (185 aa)
stat6Signal transducer and activator of transcription. (758 aa)
stat5aSignal transducer and activator of transcription. (785 aa)
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. (284 aa)
stat1aSignal transducer and activator of transcription. (749 aa)
zgc:171927Zgc:171927. (210 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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