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aldh3b1 aldh3b1 atf4a atf4a aldh3b2 aldh3b2 aldh3a1 aldh3a1 notch1a notch1a e2f1 e2f1 pxdn pxdn tp53 tp53 insb insb nubp2 nubp2 e2f3 e2f3 mafa mafa aldh3a2b aldh3a2b myca myca zmiz1a zmiz1a ar ar slc2a2 slc2a2 mafaa mafaa aldh1a3 aldh1a3 nfatc1 nfatc1 cd81a cd81a ins ins notch1b notch1b smad3a smad3a rfx3 rfx3 aldh3a2a aldh3a2a atf3 atf3 gcgrb gcgrb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
aldh3b1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (473 aa)
atf4aCyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. May play a role in the regulation of the circadian clock (By similarity). (339 aa)
aldh3b2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (502 aa)
aldh3a1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
e2f1E2F transcription factor 1. (429 aa)
pxdnPeroxidasin. (1460 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
nubp2Cytosolic Fe-S cluster assembly factor nubp2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The nubp1-nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (269 aa)
e2f3E2F transcription factor 3. (429 aa)
mafaV-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a); Belongs to the bZIP family. (325 aa)
aldh3a2bAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (490 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
zmiz1aZinc finger, MIZ-type-containing 1a. (1024 aa)
arAndrogen receptor. (868 aa)
slc2a2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (504 aa)
mafaaTranscription factor MafAa; Transcription factor, possibly involved in transcription regulation during lens development, including that of crystallin genes. Specifically binds to the alphaCE2 enhancer element of crystallin gene. (315 aa)
aldh1a3Retinaldehyde dehydrogenase family 1 subfamily A3; Belongs to the aldehyde dehydrogenase family. (513 aa)
nfatc1Nuclear factor of-activated T cells 1. (867 aa)
cd81aTetraspanin. (236 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
notch1bNotch receptor 1b. (2465 aa)
smad3aMothers against decapentaplegic homolog. (425 aa)
rfx3Transcription factor RFX3; Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development; Belongs to the RFX family. (765 aa)
aldh3a2aAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (488 aa)
atf3Activating transcription factor 3. (202 aa)
gcgrbGlucagon receptor b; Belongs to the G-protein coupled receptor 2 family. (509 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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