STRINGSTRING
asb5b asb5b actn3b actn3b prkacab prkacab mybpc1 mybpc1 plek2 plek2 isl1 isl1 fgf8a fgf8a hand2 hand2 cx36.7 cx36.7 prkacba prkacba tnnc1a tnnc1a rbpms2b rbpms2b tpm4a tpm4a myl7 myl7 celf1 celf1 atp2a2a atp2a2a atp2a1 atp2a1 cmlc1 cmlc1 acta1b acta1b actc1a actc1a rbpms2a rbpms2a rbfox2 rbfox2 prkacbb prkacbb slc8a1a slc8a1a mef2ca mef2ca myh7 myh7 ttn.2 ttn.2 actc1c actc1c ENSDARP00000100434 ENSDARP00000100434 rbfox1 rbfox1 ttn.1 ttn.1 myh6 myh6 nppa nppa ccser2a ccser2a cacnb2b cacnb2b actn2b actn2b tnni1b tnni1b tnnt2a tnnt2a nova2 nova2 plek plek myom2a myom2a me2 me2 cacnb2a cacnb2a plekha7a plekha7a ryr2b ryr2b pdlim5a pdlim5a gata4 gata4 prkacaa prkacaa rbm24a rbm24a smyhc2-2 smyhc2-2 pdlim5b pdlim5b rbp4 rbp4 mybpc3 mybpc3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
asb5bAnkyrin repeat and SOCS box-containing 5b. (328 aa)
actn3bActinin alpha 3b. (898 aa)
prkacabProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
mybpc1Myosin-binding protein C1. (1167 aa)
plek2Plek2 protein. (361 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
hand2Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis. (205 aa)
cx36.7Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (362 aa)
prkacbaProtein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa)
tnnc1aTroponin C type 1a (slow). (161 aa)
rbpms2bRNA-binding protein, mRNA-processing factor 2b. (200 aa)
tpm4aTropomyosin 4a; Belongs to the tropomyosin family. (284 aa)
myl7Myosin, light polypeptide 7, regulatory. (172 aa)
celf1CUGBP Elav-like family member 1; RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in mRNA translation activation and stability (By similarity). Involved in the regulation of muscle-specific splicing of alpha actinin pre-mRNAs via the binding to the UR-repeat element (URE) at the branch point of the non-muscle (NM) exon; Belongs to the CELF/BRUNOL family. (534 aa)
atp2a2aCalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (996 aa)
atp2a1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1005 aa)
cmlc1Cardiac myosin light chain-1. (196 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
actc1aActin, alpha, cardiac muscle 1a. (377 aa)
rbpms2aRNA-binding protein, mRNA-processing factor 2a; RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (By similarity). RNA-binding protein localized in Balbiani body (electron-dense aggregates in the oocyte) and germ plasm during oogenesis, and may be required to maintain germ plasm mRNA translational repression. Translational regulator during topographic map formation in the visual system. Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable). ECO:0000250|UniProtKB:Q9W6I1. (199 aa)
rbfox2RNA-binding fox-1 homolog 2. (241 aa)
prkacbbProtein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
slc8a1aSolute carrier family 8 member 1a; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (969 aa)
mef2caMyocyte enhancer factor 2ca. (465 aa)
myh7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
ttn.2Titin, tandem duplicate 2. (26265 aa)
actc1cActin alpha cardiac muscle 1a. (377 aa)
ENSDARP00000100434Actin alpha cardiac muscle 1a. (377 aa)
rbfox1RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons (By similarity). (373 aa)
ttn.1Titin, tandem duplicate 1. (29152 aa)
myh6Myosin, heavy chain 6, cardiac muscle, alpha; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1936 aa)
nppaNatriuretic peptide A. (139 aa)
ccser2aCoiled-coil serine-rich protein 2a. (967 aa)
cacnb2bVoltage-dependent calcium channel beta 2a subunit. (377 aa)
actn2bActinin, alpha 2b. (894 aa)
tnni1bTroponin I type 1b (skeletal, slow). (182 aa)
tnnt2aTroponin T type 2a (cardiac). (282 aa)
nova2NOVA alternative-splicing regulator 2. (517 aa)
plekPleckstrin. (352 aa)
myom2aMyomesin 2a. (1366 aa)
me2Malic enzyme. (581 aa)
cacnb2aCalcium channel, voltage-dependent, beta 2a. (636 aa)
plekha7aPleckstrin homology domain-containing family A member 7; Required for zonula adherens biogenesis and maintenance. (1264 aa)
ryr2bRyanodine receptor 2b (cardiac). (4878 aa)
pdlim5aPDZ and LIM domain 5a. (551 aa)
gata4GATA-binding protein 4. (352 aa)
prkacaaProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa)
rbm24aRNA-binding protein 24; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embry [...] (230 aa)
smyhc2-2Slow myosin heavy chain 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (184 aa)
pdlim5bPDZ and LIM domain 5b. (628 aa)
rbp4Retinol-binding protein 4, plasma; Belongs to the calycin superfamily. Lipocalin family. (192 aa)
mybpc3Myosin-binding protein C3. (1287 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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