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smad1 smad1 casp3a casp3a rho rho bmp2a bmp2a banf1 banf1 her15.1 her15.1 shhb shhb gapdhs gapdhs gapdh gapdh cltca cltca bmp4 bmp4 nog3 nog3 casp3b casp3b ndr1 ndr1 nog1 nog1 endog endog gusb gusb sox2 sox2 smad2 smad2 bmp2b bmp2b nog2 nog2 grna grna spaw spaw tgfb2 tgfb2 shha shha pak1 pak1 bmp5 bmp5 pax6a pax6a pak2a pak2a pax7a pax7a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
smad1Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. (472 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
rhoRhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (354 aa)
bmp2aBone morphogenetic protein 2a. (386 aa)
banf1Barrier-to-autointegration factor; Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non- specific dsDNA-binding sites which may promote DNA cross-bridging (By similarity). (90 aa)
her15.1Hairy and enhancer of split-related 15, tandem duplicate 1. (149 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
gapdhsGlyceraldehyde-3-phosphate dehydrogenase 2; Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. (335 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
cltcaClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1680 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
nog3Noggin-3; May function as an inhibitor of bone morphogenetic proteins (BMP) signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and BMP2/4. Not involved in organizer function or early phases of dorsoventral pattern formation; Belongs to the noggin family. (223 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
ndr1Nodal-related 1. (392 aa)
nog1Noggin-1; Inhibitor of bone morphogenetic proteins (BMP) signaling. May play an important role in the dorsoventral patterning of the embryo; Belongs to the noggin family. (216 aa)
endogEndonuclease. (306 aa)
gusbBeta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (644 aa)
sox2Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). (315 aa)
smad2Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. (469 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
nog2Noggin-2; Inhibitor of bone morphogenetic proteins (BMP) signaling; Belongs to the noggin family. (212 aa)
grnaGranulin a. (1049 aa)
spawSouthpaw. (411 aa)
tgfb2Transforming growth factor, beta 2. (413 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
pak1Non-specific serine/threonine protein kinase. (587 aa)
bmp5Bone morphogenetic protein 5. (446 aa)
pax6aPaired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa)
pak2aNon-specific serine/threonine protein kinase. (518 aa)
pax7aTranscription factor PAX7C. (507 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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