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pdcd4b pdcd4b sf3b6 sf3b6 casp3a casp3a apaf1 apaf1 hsp70.3 hsp70.3 chuk chuk vdac2 vdac2 pink1 pink1 xiap xiap aurka aurka phb2b phb2b eif3m eif3m phf5a phf5a atg101 atg101 phb2a phb2a fundc1 fundc1 mff mff atg13 atg13 pgam5 pgam5 casp9 casp9 keap1a keap1a siah1 siah1 ptk2ab ptk2ab map1lc3a map1lc3a tgfbr2b tgfbr2b gabarapl2 gabarapl2 bnip3lb bnip3lb ucp1 ucp1 zgc:73226 zgc:73226 bnip3la bnip3la cycsb cycsb bnip4 bnip4 fis1 fis1 runx3 runx3 tollip tollip bnip3 bnip3 epob epob casp22 casp22 foxo1a foxo1a tlcd3a tlcd3a map1lc3c map1lc3c sncaip sncaip asxl1 asxl1 vdac3 vdac3 nbr1a nbr1a zgc:110130 zgc:110130 bcl2l1 bcl2l1 huwe1 huwe1 sqstm1 sqstm1 stx17 stx17 ulk1b ulk1b runx1 runx1 hsp70.1 hsp70.1 epoa epoa zic1 zic1 bcl2l11 bcl2l11 runx2a runx2a casp8 casp8 opa1 opa1 jund jund casp3b casp3b cers6 cers6 fkbp8 fkbp8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pdcd4bProgrammed cell death 4b. (470 aa)
sf3b6Splicing factor 3b, subunit 6. (125 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
apaf1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). (1261 aa)
hsp70.3Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. (643 aa)
chukInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (758 aa)
vdac2Voltage-dependent anion channel 2. (283 aa)
pink1PTEN-induced kinase 1. (574 aa)
xiapX-linked inhibitor of apoptosis. (405 aa)
aurkaAurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
phb2bProhibitin. (303 aa)
eif3mEukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (375 aa)
phf5aPHD finger protein 5A. (110 aa)
atg101Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Belongs to the ATG101 family. (218 aa)
phb2aProhibitin. (302 aa)
fundc1FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control; Belongs to the FUN14 family. (152 aa)
mffMitochondrial fission factor homolog B; Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (By similarity); Belongs to the Tango11 family. (230 aa)
atg13Autophagy-related protein 13; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. (503 aa)
pgam5Serine/threonine-protein phosphatase PGAM5, mitochondrial; Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics (By similarity). May be a central mediator for programmed necrosis (By similarity); Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (289 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (436 aa)
keap1aKelch-like ECH-associated protein 1A; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non- enzymatic covalent modifications of highly reactive cystei [...] (601 aa)
siah1E3 ubiquitin-protein ligase Siah1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates; Belongs to the SINA (Seven in absentia) family. (286 aa)
ptk2abProtein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1050 aa)
map1lc3aMicrotubule-associated protein 1 light chain 3 alpha. (121 aa)
tgfbr2bTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (556 aa)
gabarapl2GABA(A) receptor-associated protein-like 2. (117 aa)
bnip3lbBCL2-interacting protein 3-like b. (213 aa)
ucp1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
zgc:73226Zgc:73226. (187 aa)
bnip3laBCL2/adenovirus E1B interacting protein 3-like, 2. (233 aa)
cycsbCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (104 aa)
bnip4BCL2-interacting protein 4. (177 aa)
fis1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (153 aa)
runx3Runt-related transcription factor. (438 aa)
tollipToll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). (276 aa)
bnip3BCL2-interacting protein 3. (183 aa)
epobErythropoietin b. (217 aa)
casp22Caspase 22, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (376 aa)
foxo1aForkhead box protein O1-A; Transcriptional regulator of cell cycle arrest required for cellular stress responses (By similarity). May be involved in regulating cellular homeostasis in the eye. (652 aa)
tlcd3aTLC domain-containing 3A. (277 aa)
map1lc3cMicrotubule-associated protein 1 light chain 3 gamma. (128 aa)
sncaipSynuclein, alpha-interacting protein. (738 aa)
asxl1ASXL transcriptional regulator 1. (1619 aa)
vdac3Voltage-dependent anion channel 3. (318 aa)
nbr1aNBR1 autophagy cargo receptor a. (989 aa)
zgc:110130Mitochondrial fission factor homolog A; Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (By similarity); Belongs to the Tango11 family. (286 aa)
bcl2l1Bcl-XL-like protein 1. (238 aa)
huwe1HECT, UBA and WWE domain-containing E3 ubiquitin protein ligase 1. (4474 aa)
sqstm1Sequestosome 1. (452 aa)
stx17Syntaxin 17. (292 aa)
ulk1bUnc-51-like autophagy-activating kinase 1. (1011 aa)
runx1Runt-related transcription factor. (451 aa)
hsp70.1Heat shock cognate 70-kd protein, tandem duplicate 1; Belongs to the heat shock protein 70 family. (643 aa)
epoaErythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Belongs to the EPO/TPO family. (183 aa)
zic1ZIC family member 1 (Odd-paired homolog, Drosophila). (442 aa)
bcl2l11BCL2-like 11. (176 aa)
runx2aRunt-related transcription factor. (467 aa)
casp8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (476 aa)
opa1Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). (966 aa)
jundJunD proto-oncogene, AP-1 transcription factor subunit. (283 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
cers6Ceramide synthase 6. (391 aa)
fkbp8Peptidylprolyl isomerase. (406 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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