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rhoab rhoab casp3a casp3a bdnf bdnf chd8 chd8 ank2b ank2b dlg4 dlg4 oxtr oxtr foxp2 foxp2 oxt oxt foxp1b foxp1b ube3a ube3a ptenb ptenb dyrk1aa dyrk1aa hdac5 hdac5 rabif rabif prok1 prok1 mtor mtor mecp2 mecp2 cntnap3 cntnap3 shank3b shank3b arhgef10 arhgef10 cdc42 cdc42 TRAPPC9 TRAPPC9 akt1 akt1 tsc2 tsc2 pcdh10b pcdh10b cntn4 cntn4 gphnb gphnb gphna gphna hdac4 hdac4 ctnnb1 ctnnb1 arid1b arid1b chd9 chd9 pcdh10a pcdh10a dip2a dip2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (270 aa)
chd8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/tp53-mediated apoptosis by recruiting histone H1 and preventing p53/tp53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (ctnnb1) activity. Negatively regulates ctnnb1-targeted gene expression by being recruited specifically to the promoter regions of several ctnnb1 responsive [...] (2555 aa)
ank2bAnkyrin 2b, neuronal. (312 aa)
dlg4Disks large homolog 4; Plays a role in synapse assembly and function. Plays a role in synaptic plasticity. (707 aa)
oxtrIsotocin receptor-like 2; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (388 aa)
foxp2Forkhead box P2. (697 aa)
oxtOxytocin; Belongs to the vasopressin/oxytocin family. (154 aa)
foxp1bForkhead box protein P1-B; Transcriptional repressor. (659 aa)
ube3aUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (857 aa)
ptenbPhosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa)
dyrk1aaDual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A, a. (737 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1128 aa)
rabifRAB-interacting factor. (132 aa)
prok1Zgc:171925 protein. (105 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
mecp2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (524 aa)
cntnap3Contactin-associated protein family member 3. (1271 aa)
shank3bSH3 and multiple ankyrin repeat domains 3b. (1631 aa)
arhgef10Rho guanine nucleotide exchange factor (GEF) 10. (1239 aa)
cdc42Cell division cycle 42. (191 aa)
TRAPPC9Si:dkey-218f9.10. (995 aa)
akt1Non-specific serine/threonine protein kinase. (247 aa)
tsc2TSC complex subunit 2. (1674 aa)
pcdh10bProtocadherin 10b. (1026 aa)
cntn4Contactin 4. (1028 aa)
gphnbGephyrin2 isoform. (796 aa)
gphnaGephyrin a. (868 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
arid1bAT-rich interactive domain 1B (SWI1-like). (2122 aa)
chd9Chromodomain helicase DNA-binding protein 9. (2443 aa)
pcdh10aProtocadherin 10a. (1001 aa)
dip2aDisco-interacting protein 2 homolog A. (1610 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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