STRINGSTRING
fgf2 fgf2 mst1 mst1 crb2b crb2b mapk6 mapk6 smad4a smad4a tgfb5 tgfb5 nbeaa nbeaa skp2 skp2 ctnna2 ctnna2 ncam2 ncam2 yap1 yap1 nlgn3b nlgn3b crb3b crb3b crb2a crb2a fstb fstb pax2a pax2a egf egf rpl13a rpl13a zpr1 zpr1 gapdh gapdh tgfb1a tgfb1a gapdhs gapdhs itga9 itga9 smad3b smad3b glulc glulc vsx2 vsx2 vezf1a vezf1a lats1 lats1 tgfb3 tgfb3 amotl1 amotl1 lin7a lin7a stk3 stk3 bmpr1aa bmpr1aa prkci prkci nrxn3b nrxn3b pard3ab pard3ab mybl2b mybl2b trarg1a trarg1a paqr8 paqr8 amot amot tjp2a tjp2a tgfb1b tgfb1b epb41l5 epb41l5 mpp5a mpp5a cdk6 cdk6 cdc42 cdc42 tfdp2 tfdp2 nlk2 nlk2 gb:cr929477 gb:cr929477 tiam1a tiam1a patj patj PARD3 PARD3 tead1b tead1b dscama dscama tead3a tead3a pcdh10a pcdh10a nlgn3a nlgn3a crb3a crb3a notch1a notch1a sema5a sema5a glulb glulb crb1 crb1 pax6a pax6a glula glula
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
mst1Macrophage stimulating 1 (Hepatocyte growth factor-like); Belongs to the peptidase S1 family. Plasminogen subfamily. (709 aa)
crb2bCrumbs cell polarity complex component 2b. (1010 aa)
mapk6Extracellular signal-regulated kinase 3. (729 aa)
smad4aMothers against decapentaplegic homolog. (547 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
nbeaaNeurobeachin a. (2998 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (410 aa)
ctnna2Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system; Belongs to the vinculin/alpha-catenin family. (865 aa)
ncam2Neural cell adhesion molecule 2. (795 aa)
yap1Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin netwo [...] (442 aa)
nlgn3bNeuroligin 3b. (846 aa)
crb3bCrumbs-like protein 3b. (96 aa)
crb2aCrumbs cell polarity complex component 2a. (1466 aa)
fstbFollistatin 2. (344 aa)
pax2aPaired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa)
egfEpidermal growth factor. (1114 aa)
rpl13aRibosomal protein L13a; Belongs to the universal ribosomal protein uL13 family. (205 aa)
zpr1ZPR1 zinc finger. (441 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
gapdhsGlyceraldehyde-3-phosphate dehydrogenase 2; Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. (335 aa)
itga9Integrin, alpha 9; Belongs to the integrin alpha chain family. (1032 aa)
smad3bMothers against decapentaplegic homolog. (423 aa)
glulcGlutamine synthetase. (371 aa)
vsx2Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Mediates the differentiation of V2a interneurons (By similarity). Plays a role in eye development and organization of the neuroretina. (372 aa)
vezf1aVascular endothelial zinc finger 1a. (488 aa)
lats1LATS, large tumor suppressor, homolog 1 (Drosophila). (1068 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
amotl1Angiomotin_C domain-containing protein. (985 aa)
lin7aProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (218 aa)
stk3Serine/threonine-protein kinase 3 20kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regul [...] (492 aa)
bmpr1aaReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
prkciProtein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division. (588 aa)
nrxn3bNeurexin-3b; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. (1687 aa)
pard3abPar-3 family cell polarity regulator alpha, b. (1332 aa)
mybl2bV-myb avian myeloblastosis viral oncogene homolog-like 2b. (633 aa)
trarg1aTrafficking regulator of GLUT4 (SLC2A4) 1a. (177 aa)
paqr8Progestin and adipoQ receptor family member VIII. (352 aa)
amotAngiomotin. (1009 aa)
tjp2aTight junction protein 2a (zona occludens 2); Belongs to the MAGUK family. (1198 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
epb41l5Erythrocyte membrane protein band 4.1-like 5. (461 aa)
mpp5aMAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (324 aa)
cdc42Cell division cycle 42. (191 aa)
tfdp2Transcription factor. (409 aa)
nlk2Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (533 aa)
gb:cr929477SMAD family member 4. (332 aa)
tiam1aTIAM Rac1-associated GEF 1a. (1621 aa)
patjPATJ crumbs cell polarity complex component. (1914 aa)
PARD3Par-3 family cell polarity regulator. (531 aa)
tead1bTEA domain family member 1b. (410 aa)
dscamaDown syndrome cell adhesion molecule a. (2036 aa)
tead3aTranscriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (409 aa)
pcdh10aProtocadherin 10a. (1001 aa)
nlgn3aNeuroligin 3a. (878 aa)
crb3aCrumbs-like protein 3a. (109 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
sema5aSemaphorin-5A. (1048 aa)
glulbGlutamine synthetase. (372 aa)
crb1Crumbs cell polarity complex component 1. (1428 aa)
pax6aPaired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa)
glulaGlutamine synthetase. (371 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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