STRINGSTRING
cfl2 cfl2 actn3b actn3b cfl1l cfl1l rho rho bmp2a bmp2a cfl1 cfl1 ptk2ab ptk2ab atat1 atat1 ins ins pfn2l pfn2l acta1b acta1b map1b map1b pxnb pxnb vaspb vaspb yap1 yap1 spp1 spp1 mapk3 mapk3 pfn2 pfn2 vclb vclb vcla vcla neurog3 neurog3 bmp2b bmp2b pfn1 pfn1 insb insb wnt8a wnt8a wnt8-2 wnt8-2 X1WCU6_DANRE X1WCU6_DANRE tln1 tln1 tln2a tln2a cdh1 cdh1 lmnb2 lmnb2 vaspa vaspa pparg pparg pxna pxna tln2b tln2b lmna lmna
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
actn3bActinin alpha 3b. (898 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
rhoRhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (354 aa)
bmp2aBone morphogenetic protein 2a. (386 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
ptk2abProtein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1050 aa)
atat1Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (305 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
pfn2lProfilin; Belongs to the profilin family. (139 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
map1bHypothetical microtubule-associated protein 1b. (2033 aa)
pxnbPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (525 aa)
vaspbVasodilator-stimulated phosphoprotein b. (445 aa)
yap1Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin netwo [...] (442 aa)
spp1Secreted phosphoprotein 1. (305 aa)
mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
pfn2Profilin; Belongs to the profilin family. (140 aa)
vclbVinculin b. (987 aa)
vclaVinculin a. (1131 aa)
neurog3Neurog3 protein. (208 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
pfn1Profilin; Belongs to the profilin family. (141 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
wnt8aProtein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis; Belongs to the Wnt family. (387 aa)
wnt8-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
X1WCU6_DANREProfilin; Belongs to the profilin family. (127 aa)
tln1Talin 1. (2544 aa)
tln2aTalin 2a. (2543 aa)
cdh1Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa)
lmnb2Lamin B2; Belongs to the intermediate filament family. (583 aa)
vaspaVasodilator-stimulated phosphoprotein a. (412 aa)
ppargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa)
pxnaPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (532 aa)
tln2bTalin 2b. (1537 aa)
lmnaLamin A; Belongs to the intermediate filament family. (675 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.