(24 nodes) (2023) Resveratrol Modulates the Redox Response and Bile Acid Metabolism to Maintain the Cholesterol Homeostasis in Fish Megalobrama amblycephala Offered a High-Carbohydrate Diet. network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

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protein homology

Your Input:
	gpx7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
	cyp8b2	Cytochrome P450, family 8, subfamily B, polypeptide 2. (525 aa)
	cyp8b3	Cytochrome P450, family 8, subfamily B, polypeptide 3. (513 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (441 aa)
	eef1a1l1	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa)
	gpx4b	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (170 aa)
	gpx1b	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
	gpx8	Probable glutathione peroxidase 8; Belongs to the glutathione peroxidase family. (210 aa)
	gpx1a	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (191 aa)
	keap1a	Kelch-like ECH-associated protein 1A; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non- enzymatic covalent modifications of highly reactive cystei [...] (601 aa)
	abcb11a	ATP-binding cassette, sub-family B (MDR/TAP), member 11a. (1320 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (483 aa)
	sod2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
	gpx3	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (222 aa)
	sod1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
	sqleb	Squalene epoxidase b. (493 aa)
	srebf2	Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity). (1095 aa)
	sirt1	Sirtuin 1. (710 aa)
	gpx4a	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
	cyp8b1	Cytochrome P450, family 8, subfamily B, polypeptide 1. (521 aa)
	abcb11b	ATP-binding cassette, sub-family B (MDR/TAP), member 11b. (1308 aa)
	sqlea	Squalene epoxidase a. (557 aa)
	cyp7a1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (512 aa)
	gpx9	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (140 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
abcb11a	abcb11b	ENSDARP00000047400	ENSDARP00000093333	ATP-binding cassette, sub-family B (MDR/TAP), member 11a.	ATP-binding cassette, sub-family B (MDR/TAP), member 11b.	0.902
abcb11a	cyp7a1	ENSDARP00000047400	ENSDARP00000113850	ATP-binding cassette, sub-family B (MDR/TAP), member 11a.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.765
abcb11a	cyp8b1	ENSDARP00000047400	ENSDARP00000091773	ATP-binding cassette, sub-family B (MDR/TAP), member 11a.	Cytochrome P450, family 8, subfamily B, polypeptide 1.	0.665
abcb11a	nr1h4	ENSDARP00000047400	ENSDARP00000061793	ATP-binding cassette, sub-family B (MDR/TAP), member 11a.	Nuclear receptor subfamily 1, group H, member 4.	0.840
abcb11a	sod2	ENSDARP00000047400	ENSDARP00000062555	ATP-binding cassette, sub-family B (MDR/TAP), member 11a.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.429
abcb11b	abcb11a	ENSDARP00000093333	ENSDARP00000047400	ATP-binding cassette, sub-family B (MDR/TAP), member 11b.	ATP-binding cassette, sub-family B (MDR/TAP), member 11a.	0.902
abcb11b	cyp7a1	ENSDARP00000093333	ENSDARP00000113850	ATP-binding cassette, sub-family B (MDR/TAP), member 11b.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.775
abcb11b	cyp8b1	ENSDARP00000093333	ENSDARP00000091773	ATP-binding cassette, sub-family B (MDR/TAP), member 11b.	Cytochrome P450, family 8, subfamily B, polypeptide 1.	0.635
abcb11b	nr1h4	ENSDARP00000093333	ENSDARP00000061793	ATP-binding cassette, sub-family B (MDR/TAP), member 11b.	Nuclear receptor subfamily 1, group H, member 4.	0.862
abcb11b	sod2	ENSDARP00000093333	ENSDARP00000062555	ATP-binding cassette, sub-family B (MDR/TAP), member 11b.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.429
cyp7a1	abcb11a	ENSDARP00000113850	ENSDARP00000047400	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	ATP-binding cassette, sub-family B (MDR/TAP), member 11a.	0.765
cyp7a1	abcb11b	ENSDARP00000113850	ENSDARP00000093333	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	ATP-binding cassette, sub-family B (MDR/TAP), member 11b.	0.775
cyp7a1	nr1h3	ENSDARP00000113850	ENSDARP00000139970	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Nuclear receptor subfamily 1, group H, member 3.	0.641
cyp7a1	nr1h4	ENSDARP00000113850	ENSDARP00000061793	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Nuclear receptor subfamily 1, group H, member 4.	0.882
cyp7a1	sqlea	ENSDARP00000113850	ENSDARP00000098511	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Squalene epoxidase a.	0.697
cyp7a1	sqleb	ENSDARP00000113850	ENSDARP00000086840	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Squalene epoxidase b.	0.738
cyp7a1	srebf2	ENSDARP00000113850	ENSDARP00000087122	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity).	0.586
cyp8b1	abcb11a	ENSDARP00000091773	ENSDARP00000047400	Cytochrome P450, family 8, subfamily B, polypeptide 1.	ATP-binding cassette, sub-family B (MDR/TAP), member 11a.	0.665
cyp8b1	abcb11b	ENSDARP00000091773	ENSDARP00000093333	Cytochrome P450, family 8, subfamily B, polypeptide 1.	ATP-binding cassette, sub-family B (MDR/TAP), member 11b.	0.635
cyp8b1	cyp8b2	ENSDARP00000091773	ENSDARP00000128795	Cytochrome P450, family 8, subfamily B, polypeptide 1.	Cytochrome P450, family 8, subfamily B, polypeptide 2.	0.902

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