STRINGSTRING
casp3a casp3a hsp70.3 hsp70.3 tnfb tnfb bdnf bdnf igf1ra igf1ra myd88 myd88 tgfb3 tgfb3 gfap gfap caspa caspa fosab fosab igf1rb igf1rb nos2b nos2b crp2 crp2 tgfb1a tgfb1a mmp9 mmp9 casp3b casp3b stat3 stat3 crp1 crp1 crp6 crp6 tgfb5 tgfb5 il10 il10 crp7 crp7 crp3 crp3 nos2a nos2a hsp70.1 hsp70.1 crp2-2 crp2-2 caspbl caspbl tgfb1b tgfb1b hmgb1a hmgb1a nos1 nos1 il1b il1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
hsp70.3Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. (643 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (270 aa)
igf1raTyrosine-protein kinase receptor. (1405 aa)
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. (284 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
gfapGlial fibrillary acidic protein; Belongs to the intermediate filament family. (444 aa)
caspaCaspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] (383 aa)
fosabV-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (349 aa)
igf1rbTyrosine-protein kinase receptor. (1380 aa)
nos2bNitric oxide synthase; Produces nitric oxide (NO). (1077 aa)
crp2Pentaxin. (222 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
mmp9Matrix metallopeptidase 9. (680 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
stat3Signal transducer and activator of transcription. (806 aa)
crp1Pentaxin. (225 aa)
crp6Pentaxin. (225 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
il10Interleukin-10. (180 aa)
crp7Pentaxin. (225 aa)
crp3Pentaxin. (223 aa)
nos2aNitric oxide synthase; Produces nitric oxide (NO). (1079 aa)
hsp70.1Heat shock cognate 70-kd protein, tandem duplicate 1; Belongs to the heat shock protein 70 family. (643 aa)
crp2-2Pentaxin. (225 aa)
caspblCaspase b,-like; Belongs to the peptidase C14A family. (409 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
hmgb1aHigh mobility group box 1a. (205 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
il1bInterleukin-1. (284 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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