(28 nodes) (2023) Immune-Epithelial Cross Talk in Regeneration and Repair. network (Danio rerio)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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Your Input:
	stat3	Signal transducer and activator of transcription. (806 aa)
	ccr2	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	ccr2-2	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	ctnnb1	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
	notch1a	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
	il4r.1	Interleukin 4 receptor, tandem duplicate 1. (220 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
	egfra	Epidermal growth factor receptor precursor. (625 aa)
	ccl20b	C-C motif chemokine. (102 aa)
	tgfb1b	Transforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
	vegfd	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (272 aa)
	jag1a	Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1253 aa)
	il10	Interleukin-10. (180 aa)
	lrig1	Leucine-rich repeats and immunoglobulin-like domains 1. (1022 aa)
	si:dkey-32n7.4	Si:dkey-32n7.4; Belongs to the integrin alpha chain family. (1136 aa)
	stat1a	Signal transducer and activator of transcription. (749 aa)
	gata3	Transcription factor GATA-3. (438 aa)
	tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
	porcn	Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (442 aa)
	tgfb1a	Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
	jun	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
	il22	Interleukin 22. (213 aa)
	pdgfc	Platelet-derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (343 aa)
	wnt1	Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Involved in neurogenesis. Performs a partially redundant function with wnt10b in the formation of the midbrain-hindbrain boundary (MHB) organizer. In the hindbrain, mediates lateral inhibition of boundary cell specification, probably via up-regulation of proneural and Delta gene expression in non-boundary cells; localized expression of wnt1 in boundary cells is maintained vi [...] (370 aa)
	foxp3a	Forkhead box protein. (419 aa)
	dot1l	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1454 aa)
	vegfc	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa)
	tgfb5	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ccl20b	ccr2	ENSDARP00000122912	ENSDARP00000142081	C-C motif chemokine.	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.686
ccl20b	ccr2-2	ENSDARP00000122912	ENSDARP00000142057	C-C motif chemokine.	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.686
ccl20b	foxp3a	ENSDARP00000122912	ENSDARP00000080214	C-C motif chemokine.	Forkhead box protein.	0.451
ccl20b	il10	ENSDARP00000122912	ENSDARP00000098423	C-C motif chemokine.	Interleukin-10.	0.687
ccl20b	stat1a	ENSDARP00000122912	ENSDARP00000015753	C-C motif chemokine.	Signal transducer and activator of transcription.	0.402
ccl20b	stat3	ENSDARP00000122912	ENSDARP00000095292	C-C motif chemokine.	Signal transducer and activator of transcription.	0.400
ccr2	ccl20b	ENSDARP00000142081	ENSDARP00000122912	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.686
ccr2	ccr2-2	ENSDARP00000142081	ENSDARP00000142057	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.900
ccr2	foxp3a	ENSDARP00000142081	ENSDARP00000080214	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	Forkhead box protein.	0.555
ccr2	il10	ENSDARP00000142081	ENSDARP00000098423	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	Interleukin-10.	0.849
ccr2	stat3	ENSDARP00000142081	ENSDARP00000095292	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	Signal transducer and activator of transcription.	0.545
ccr2-2	ccl20b	ENSDARP00000142057	ENSDARP00000122912	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.686
ccr2-2	ccr2	ENSDARP00000142057	ENSDARP00000142081	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.900
ccr2-2	foxp3a	ENSDARP00000142057	ENSDARP00000080214	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	Forkhead box protein.	0.555
ccr2-2	il10	ENSDARP00000142057	ENSDARP00000098423	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	Interleukin-10.	0.849
ccr2-2	stat3	ENSDARP00000142057	ENSDARP00000095292	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	Signal transducer and activator of transcription.	0.545
ctnnb1	dot1l	ENSDARP00000139205	ENSDARP00000083509	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...]	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	0.436
ctnnb1	egfra	ENSDARP00000139205	ENSDARP00000125265	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...]	Epidermal growth factor receptor precursor.	0.987
ctnnb1	fgf2	ENSDARP00000139205	ENSDARP00000132803	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.732
ctnnb1	foxp3a	ENSDARP00000139205	ENSDARP00000080214	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...]	Forkhead box protein.	0.400

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