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her7 her7 aldh3b1 aldh3b1 tbx16 tbx16 lft1 lft1 myod1 myod1 dlc dlc fgf8a fgf8a her1 her1 aldh3a2a aldh3a2a myf6 myf6 tdgf1 tdgf1 chrd chrd pitx2 pitx2 dand5 dand5 acta1b acta1b lft2 lft2 aldh1a2 aldh1a2 nog3 nog3 nog1 nog1 msgn1 msgn1 aldh3a2b aldh3a2b myf5 myf5 nog2 nog2 spaw spaw bicc1b bicc1b sox17 sox17 notch1a notch1a aldh3a1 aldh3a1 aldh3b2 aldh3b2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
her7Hairy and enhancer of split-related-7. (206 aa)
aldh3b1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (473 aa)
tbx16T-box transcription factor 16. (470 aa)
lft1Left-right determination factor; Belongs to the TGF-beta family. (358 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
dlcDelta-like protein C; Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. (664 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
her1Hairy-related 1. (328 aa)
aldh3a2aAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (488 aa)
myf6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (239 aa)
tdgf1Teratocarcinoma-derived growth factor 1. (190 aa)
chrdChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa)
pitx2Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa)
dand5DAN domain family, member 5. (243 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
lft2Left-right determination factor. (362 aa)
aldh1a2Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
nog3Noggin-3; May function as an inhibitor of bone morphogenetic proteins (BMP) signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and BMP2/4. Not involved in organizer function or early phases of dorsoventral pattern formation; Belongs to the noggin family. (223 aa)
nog1Noggin-1; Inhibitor of bone morphogenetic proteins (BMP) signaling. May play an important role in the dorsoventral patterning of the embryo; Belongs to the noggin family. (216 aa)
msgn1Mesogenin-1; Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity). (131 aa)
aldh3a2bAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (490 aa)
myf5Myogenic factor. (237 aa)
nog2Noggin-2; Inhibitor of bone morphogenetic proteins (BMP) signaling; Belongs to the noggin family. (212 aa)
spawSouthpaw. (411 aa)
bicc1bBicC family RNA-binding protein 1b. (581 aa)
sox17SRY-box transcription factor 17. (413 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
aldh3a1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa)
aldh3b2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (502 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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