STRINGSTRING
slc2a3a slc2a3a cd27 cd27 hdac4 hdac4 map3k1 map3k1 card11 card11 arfgap3 arfgap3 il21r.1 il21r.1 itgb2 itgb2 il23r il23r tgfb1b tgfb1b plcg1 plcg1 il7r il7r ccr7 ccr7 parp8 parp8 stat5b stat5b bcl6aa bcl6aa il13 il13 il10 il10 tgfb5 tgfb5 stat3 stat3 mapk3 mapk3 foxp3a foxp3a raraa raraa cdkn1bb cdkn1bb il22 il22 cxcr4b cxcr4b tgfb1a tgfb1a fosl2 fosl2 jak3 jak3 tgfbr2b tgfbr2b tgfb3 tgfb3 stat5a stat5a gata3 gata3 tlr3 tlr3 tbx21 tbx21 il12rb2 il12rb2 pik3cg pik3cg
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
slc2a3aSolute carrier family 2 member 3a; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (550 aa)
cd27CD27 molecule. (248 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa)
map3k1Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase. (1334 aa)
card11Caspase recruitment domain family, member 11. (1110 aa)
arfgap3ADP-ribosylation factor GTPase-activating protein 3. (497 aa)
il21r.1Interleukin 21 receptor, tandem duplicate 1. (523 aa)
itgb2Integrin beta. (768 aa)
il23rInterleukin 23 receptor. (817 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
plcg1Phosphoinositide phospholipase C. (1020 aa)
il7rInterleukin 7 receptor. (372 aa)
ccr7Chemokine (C-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (385 aa)
parp8Poly (ADP-ribose) polymerase family, member 8. (861 aa)
stat5bSignal transducer and activator of transcription. (786 aa)
bcl6aaBCL6A transcription repressor a. (718 aa)
il13Interleukin 4/13A. (157 aa)
il10Interleukin-10. (180 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
stat3Signal transducer and activator of transcription. (806 aa)
mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
foxp3aForkhead box protein. (419 aa)
raraaRetinoic acid receptor alpha-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain patterning; Belongs to the nuclear hormone receptor family. NR1 subfamily. (444 aa)
cdkn1bbCyclin-dependent kinase inhibitor 1b (P27, kip1). (179 aa)
il22Interleukin 22. (213 aa)
cxcr4bChemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
fosl2FOS-like 2, AP-1 transcription factor subunit. (341 aa)
jak3Tyrosine-protein kinase. (1103 aa)
tgfbr2bTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (556 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
stat5aSignal transducer and activator of transcription. (785 aa)
gata3Transcription factor GATA-3. (438 aa)
tlr3Toll-like receptor 3; Belongs to the Toll-like receptor family. (903 aa)
tbx21T-box transcription factor 21. (609 aa)
il12rb2Interleukin 12 receptor beta 2.a. (792 aa)
pik3cgPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1098 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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