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acta1b acta1b ankrd2 ankrd2 mylpfa mylpfa E7F8P5_DANRE E7F8P5_DANRE prss12 prss12 myh7 myh7 mstnb mstnb trdn trdn pik3c3 pik3c3 tnnc2 tnnc2 tpm1 tpm1 tnni4b.2 tnni4b.2 tpma tpma pparg pparg obscnb obscnb Trdn Trdn smyhc2-2 smyhc2-2 utrn utrn casq1a casq1a agrn agrn usp3 usp3 neb neb myl2b myl2b insb insb myf5 myf5 ttn.1 ttn.1 ace2 ace2 myhz1.1 myhz1.1 ace ace ptprc ptprc tnni1a tnni1a actn3b actn3b sp3a sp3a dmd dmd mybpc1 mybpc1 bdnf bdnf casq1b casq1b F1QX88_DANRE F1QX88_DANRE casq2 casq2 tcap tcap tpm4a tpm4a tnni2a.4 tnni2a.4 myoz2a myoz2a ins ins
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
acta1bActin alpha 1, skeletal muscle b. (377 aa)
ankrd2Ankyrin repeat domain 2 (stretch-responsive muscle). (296 aa)
mylpfaMyosin light chain, phosphorylatable, fast skeletal muscle a. (169 aa)
E7F8P5_DANRESi:ch73-127m5.1; Belongs to the peptidase S1 family. (835 aa)
prss12Serine protease 12; Belongs to the peptidase S1 family. (816 aa)
myh7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
mstnbGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog. (374 aa)
trdnTriadin. (785 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa)
tnnc2Fast skeletal muscle troponin C. (160 aa)
tpm1Tropomyosin 1 (alpha); Belongs to the tropomyosin family. (284 aa)
tnni4b.2Troponin I4b, tandem duplicate 2. (218 aa)
tpmaTropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (284 aa)
ppargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa)
obscnbObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b. (1660 aa)
TrdnSi:ch211-199i15.5. (118 aa)
smyhc2-2Slow myosin heavy chain 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (184 aa)
utrnUtrophin; May play a role in anchoring the cytoskeleton to the plasma membrane. (2632 aa)
casq1aCalsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (553 aa)
agrnAgrin. (1926 aa)
usp3Ubiquitin carboxyl-terminal hydrolase. (524 aa)
nebNebulin. (6177 aa)
myl2bMyosin, light polypeptide 2, regulatory, cardiac, slow. (168 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
myf5Myogenic factor. (237 aa)
ttn.1Titin, tandem duplicate 1. (29152 aa)
ace2Angiotensin-converting enzyme. (818 aa)
myhz1.1Myosin, heavy polypeptide 1.1, skeletal muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
aceAngiotensin-converting enzyme. (1324 aa)
ptprcProtein tyrosine phosphatase receptor type C. (1130 aa)
tnni1aTroponin I type 1a (skeletal, slow). (181 aa)
actn3bActinin alpha 3b. (898 aa)
sp3aSp3a transcription factor. (679 aa)
dmdDystrophin. (594 aa)
mybpc1Myosin-binding protein C1. (1167 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (270 aa)
casq1bCalsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (454 aa)
F1QX88_DANRESi:ch211-51a6.2; Belongs to the peptidase S1 family. (832 aa)
casq2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (409 aa)
tcapTitin-cap (telethonin). (179 aa)
tpm4aTropomyosin 4a; Belongs to the tropomyosin family. (284 aa)
tnni2a.4Troponin I type 2a (skeletal, fast), tandem duplicate 4. (176 aa)
myoz2aMyozenin 2a. (264 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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