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or111-7 or111-7 drd2b drd2b hif1ab hif1ab casp3a casp3a tnfb tnfb bdnf bdnf gpx1b gpx1b gpx8 gpx8 mapkapk2a mapkapk2a gpx1a gpx1a gsk3ba gsk3ba tlr4bb tlr4bb caspa caspa cycsb cycsb hif1aa hif1aa nos2b nos2b ache ache tgfb1a tgfb1a cryaba cryaba cebpb cebpb mmp9 mmp9 gpx3 gpx3 jun jun gsk3bb gsk3bb casp3b casp3b ctsba ctsba rel rel cdk5 cdk5 sirt1 sirt1 gpx4a gpx4a pik3c3 pik3c3 stat3 stat3 casp8 casp8 arg1 arg1 il10 il10 tlr4al tlr4al tlr4ba tlr4ba nos2a nos2a ripk3 ripk3 caspbl caspbl bcl2a bcl2a tgfb1b tgfb1b gpx7 gpx7 drd2a drd2a gpx9 gpx9 drd2l drd2l relb relb hif1al hif1al rela rela nos1 nos1 casp22 casp22 scarb1 scarb1 il1b il1b ctsbb ctsbb tle3b tle3b vcam1b vcam1b gpx4b gpx4b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
or111-7Odorant receptor, family D, subfamily 111, member 7. (325 aa)
drd2bDopamine D2c receptor; Belongs to the G-protein coupled receptor 1 family. (452 aa)
hif1abHypoxia-inducible factor 1 subunit alpha b. (777 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (270 aa)
gpx1bGlutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
gpx8Probable glutathione peroxidase 8; Belongs to the glutathione peroxidase family. (210 aa)
mapkapk2aMitogen-activated protein kinase-activated protein kinase 2a; Belongs to the protein kinase superfamily. (382 aa)
gpx1aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (191 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
tlr4bbToll-like receptor 4b, duplicate b. (819 aa)
caspaCaspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] (383 aa)
cycsbCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (104 aa)
hif1aaHypoxia-inducible factor 1 subunit alpha a. (717 aa)
nos2bNitric oxide synthase; Produces nitric oxide (NO). (1077 aa)
acheAcetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. (634 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
cryabaCrystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (168 aa)
cebpbCCAAT/enhancer-binding protein. (280 aa)
mmp9Matrix metallopeptidase 9. (680 aa)
gpx3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (222 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
gsk3bbGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (419 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
ctsbaCathepsin B, a; Belongs to the peptidase C1 family. (330 aa)
relV-rel avian reticuloendotheliosis viral oncogene homolog. (596 aa)
cdk5Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
sirt1Sirtuin 1. (710 aa)
gpx4aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa)
stat3Signal transducer and activator of transcription. (806 aa)
casp8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (476 aa)
arg1Arginase. (341 aa)
il10Interleukin-10. (180 aa)
tlr4alToll-like receptor 4a, like. (816 aa)
tlr4baToll-like receptor 4b, duplicate a. (787 aa)
nos2aNitric oxide synthase; Produces nitric oxide (NO). (1079 aa)
ripk3Receptor-interacting serine-threonine kinase 3. (361 aa)
caspblCaspase b,-like; Belongs to the peptidase C14A family. (409 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
drd2aDopamine D2a receptor; Belongs to the G-protein coupled receptor 1 family. (448 aa)
gpx9Glutathione peroxidase; Belongs to the glutathione peroxidase family. (140 aa)
drd2lDopamine receptor D2-like; Belongs to the G-protein coupled receptor 1 family. (450 aa)
relbV-rel avian reticuloendotheliosis viral oncogene homolog B. (582 aa)
hif1alHypoxia-inducible factor 1 subunit alpha,-like. (626 aa)
relaV-rel avian reticuloendotheliosis viral oncogene homolog A. (455 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
casp22Caspase 22, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (376 aa)
scarb1Scavenger receptor class B, member 1; Belongs to the CD36 family. (496 aa)
il1bInterleukin-1. (284 aa)
ctsbbCathepsin Bb; Belongs to the peptidase C1 family. (327 aa)
tle3bTransducin-like enhancer protein 3-B; Transcriptional corepressor that binds to a number of transcription factors; Belongs to the WD repeat Groucho/TLE family. (771 aa)
vcam1bVascular cell adhesion molecule 1b. (808 aa)
gpx4bGlutathione peroxidase; Belongs to the glutathione peroxidase family. (170 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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