STRINGSTRING
tub tub thrb thrb bbs12 bbs12 bbs9 bbs9 ttc8 ttc8 lztfl1 lztfl1 trim32 trim32 crhr2 crhr2 irs2b irs2b pax6a pax6a crebbpa crebbpa wdpcp wdpcp pcnt pcnt cep290 cep290 kidins220b kidins220b cep19 cep19 bbs10 bbs10 prkar1aa prkar1aa ccdc28b ccdc28b hnf1ba hnf1ba npy2r npy2r tmem67 tmem67 g6pca.1 g6pca.1 agrp agrp sh2b1 sh2b1 lepa lepa pyya pyya ucp3 ucp3 fmr1 fmr1 bbs1 bbs1 snrpd2 snrpd2 pcsk1 pcsk1 bdnf bdnf pck1 pck1 phf6 phf6 tbx3a tbx3a mc4r mc4r wt1a wt1a dyrk1b dyrk1b sim1a sim1a rps6ka3a rps6ka3a npy npy CRHR2 CRHR2 bbs5 bbs5 adcy3a adcy3a bbs2 bbs2 oxt oxt rab23 rab23 pomca pomca spg11 spg11 irs1 irs1 cpe cpe alms1 alms1 pomcb pomcb sirt1 sirt1 mc3r mc3r pou3f2b pou3f2b bbs7 bbs7 lepr lepr ptenb ptenb sim1b sim1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tubTUB bipartite transcription factor; Belongs to the TUB family. (509 aa)
thrbThyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for the thyroid gland hormone triiodothyronine (T3). Transactivating activity is ligand-dependent, and is repressed in the absence of T3. (508 aa)
bbs12Bardet-Biedl syndrome 12. (763 aa)
bbs9Bardet-Biedl syndrome 9. (842 aa)
ttc8Tetratricopeptide repeat domain 8. (268 aa)
lztfl1Leucine zipper transcription factor-like 1. (298 aa)
trim32Tripartite motif-containing 32. (663 aa)
crhr2Zgc:172101 protein. (97 aa)
irs2bInsulin receptor substrate 2b. (1062 aa)
pax6aPaired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa)
crebbpaCREB-binding protein a. (2349 aa)
wdpcpWD repeat-containing planar cell polarity effector. (707 aa)
pcntPericentrin. (4245 aa)
cep290Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] (2439 aa)
kidins220bKinase D-interacting substrate of 220 kDa B; Downstream target for both neurotrophin and ephrin receptors. May play a role in nerve growth factor (NGF)-induced recruitment of rapgef2 to late endosomes and neurite outgrowth. (1680 aa)
cep19Centrosomal protein of 19 kDa; Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation; Belongs to the CEP19 family. (161 aa)
bbs10Bardet-Biedl syndrome 10. (151 aa)
prkar1aaProtein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) a. (379 aa)
ccdc28bCoiled-coil domain-containing 28B. (213 aa)
hnf1baHepatocyte nuclear factor 1-beta-A; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of rhombomere r5/r6 gene expression in the hindbrain. (555 aa)
npy2rNeuropeptide Y receptor Y2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
tmem67Transmembrane protein 67. (982 aa)
g6pca.1Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (352 aa)
agrpAgouti-related neuropeptide. (126 aa)
sh2b1SH2B adaptor protein 1. (906 aa)
lepaPutative leptin. (166 aa)
pyyaPeptide YY-A; Belongs to the NPY family. (97 aa)
ucp3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
fmr1FMRP translational regulator 1. (569 aa)
bbs1Bardet-Biedl syndrome 1. (588 aa)
snrpd2Small nuclear ribonucleoprotein Sm D2. (118 aa)
pcsk1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (755 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (270 aa)
pck1Phosphoenolpyruvate carboxykinase 1 (soluble). (630 aa)
phf6PHD finger protein 6. (363 aa)
tbx3aT-box transcription factor 3a. (689 aa)
mc4rMelanocortin receptor 4; Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). (326 aa)
wt1aWT1 transcription factor a. (419 aa)
dyrk1bDual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1B. (751 aa)
sim1aSingle-minded homolog 1-A; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. (745 aa)
rps6ka3aRibosomal protein S6 kinase. (732 aa)
npyC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (96 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (334 aa)
bbs5Bardet-Biedl syndrome 5 protein homolog; Required for ciliogenesis; Belongs to the BBS5 family. (342 aa)
adcy3aAdenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
bbs2Bardet-Biedl syndrome 2 protein homolog; Required for ciliogenesis. (715 aa)
oxtOxytocin; Belongs to the vasopressin/oxytocin family. (154 aa)
rab23RAB23, member RAS oncogene family. (237 aa)
pomcaPro-opiomelanocortin protein. (222 aa)
spg11SPG11 vesicle-trafficking-associated, spatacsin. (1612 aa)
irs1Insulin receptor substrate 1. (1099 aa)
cpeCarboxypeptidase E. (454 aa)
alms1ALMS1 centrosome and basal body-associated protein. (2105 aa)
pomcbProopiomelanocortin b. (215 aa)
sirt1Sirtuin 1. (710 aa)
mc3rMelanocortin 3 receptor. (327 aa)
pou3f2bPOU domain, class 3, transcription factor 2; Transcription factor that may play important roles in patterning the embryonic brain; Belongs to the POU transcription factor family. Class-3 subfamily. (378 aa)
bbs7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
leprLeptin receptor. (1065 aa)
ptenbPhosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa)
sim1bSIM bHLH transcription factor 1b. (586 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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