STRINGSTRING
gadd45ga gadd45ga pfn1 pfn1 pfn2 pfn2 arpc2 arpc2 gpx4a gpx4a gabrg2 gabrg2 g6pca.2 g6pca.2 tubb1 tubb1 ccnd2a ccnd2a sod2 sod2 spc24 spc24 acta1b acta1b pfn2l pfn2l mgst3b mgst3b pgp pgp prkcbb prkcbb g6pc3 g6pc3 fth1a fth1a adrb1 adrb1 cfl1 cfl1 aqp4 aqp4 ndc80 ndc80 cfl2 cfl2 cfl1l cfl1l slc12a5b slc12a5b eef1a1l1 eef1a1l1 grm5a grm5a tbcd tbcd zgc:175088 zgc:175088 mgst3a mgst3a grm5b grm5b g6pcb g6pcb X1WCU6_DANRE X1WCU6_DANRE ddit4 ddit4 hdac6 hdac6 ercc6 ercc6 ikbkb ikbkb g6pca.1 g6pca.1 haus3 haus3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gadd45gaGrowth arrest and DNA-damage-inducible, gamma a. (159 aa)
pfn1Profilin; Belongs to the profilin family. (141 aa)
pfn2Profilin; Belongs to the profilin family. (140 aa)
arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (299 aa)
gpx4aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
gabrg2Gamma-aminobutyric acid (GABA) A receptor, gamma 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (477 aa)
g6pca.2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
tubb1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (466 aa)
ccnd2aCyclin D2, a; Belongs to the cyclin family. (298 aa)
sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
spc24Kinetochore protein Spc24; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. (202 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
pfn2lProfilin; Belongs to the profilin family. (139 aa)
mgst3bMicrosomal glutathione S-transferase 3b. (140 aa)
pgpPhosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (306 aa)
prkcbbProtein kinase C beta type; Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative [...] (670 aa)
g6pc3Glucose-6-phosphatase 3; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity); Belongs to the glucose-6-phosphatase family. (339 aa)
fth1aFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (177 aa)
adrb1Adrenergic, beta-1-, receptor. (390 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
aqp4Si:ch211-192k9.1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (320 aa)
ndc80Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores t [...] (632 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
slc12a5bSolute carrier family 12 member 5b. (1146 aa)
eef1a1l1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa)
grm5aGlutamate receptor, metabotropic 5a. (1173 aa)
tbcdTubulin folding cofactor D. (1191 aa)
zgc:175088Zgc:175088 protein. (177 aa)
mgst3aMicrosomal glutathione S-transferase 3a. (150 aa)
grm5bGlutamate receptor, metabotropic 5b. (1195 aa)
g6pcbGlucose-6-phosphatase b, catalytic subunit. (363 aa)
X1WCU6_DANREProfilin; Belongs to the profilin family. (127 aa)
ddit4DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (B [...] (220 aa)
hdac6Histone deacetylase 6. (1081 aa)
ercc6Excision repair cross-complementation group 6. (1389 aa)
ikbkbInhibitor of nuclear factor kappa B kinase subunit beta. (779 aa)
g6pca.1Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (352 aa)
haus3Augmin-like complex subunit 3-like protein beta. (645 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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